The role of viscosity on skin penetration from cellulose ether‐based hydrogels
Background The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controvers...
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| Published in: | Skin research and technology Vol. 25; no. 5; pp. 725 - 734 |
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| Main Authors: | , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
John Wiley & Sons, Inc
01.09.2019
John Wiley and Sons Inc |
| Subjects: | |
| ISSN: | 0909-752X, 1600-0846, 1600-0846 |
| Online Access: | Get full text |
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| Abstract | Background
The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration.
Materials and Methods
Hydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non‐invasive confocal Raman spectroscopy.
Results
The trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity.
Conclusion
Drug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application. |
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| AbstractList | The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration.BACKGROUNDThe rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration.Hydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non-invasive confocal Raman spectroscopy.MATERIALS AND METHODSHydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non-invasive confocal Raman spectroscopy.The trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity.RESULTSThe trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity.Drug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application.CONCLUSIONDrug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application. The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration. Hydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non-invasive confocal Raman spectroscopy. The trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity. Drug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application. BackgroundThe rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration.Materials and MethodsHydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non‐invasive confocal Raman spectroscopy.ResultsThe trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity.ConclusionDrug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application. Background The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration. Materials and Methods Hydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non‐invasive confocal Raman spectroscopy. Results The trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity. Conclusion Drug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application. |
| Author | Petz, Romana Klang, Victoria Binder, Lisa Mazál, Julia Valenta, Claudia |
| AuthorAffiliation | 2 Research Platform ‘Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms’ University of Vienna Vienna Austria 1 Department of Pharmaceutical Technology and Biopharmaceutics University of Vienna Vienna Austria |
| AuthorAffiliation_xml | – name: 1 Department of Pharmaceutical Technology and Biopharmaceutics University of Vienna Vienna Austria – name: 2 Research Platform ‘Characterisation of Drug Delivery Systems on Skin and Investigation of Involved Mechanisms’ University of Vienna Vienna Austria |
| Author_xml | – sequence: 1 givenname: Lisa surname: Binder fullname: Binder, Lisa organization: University of Vienna – sequence: 2 givenname: Julia surname: Mazál fullname: Mazál, Julia organization: University of Vienna – sequence: 3 givenname: Romana surname: Petz fullname: Petz, Romana organization: University of Vienna – sequence: 4 givenname: Victoria orcidid: 0000-0003-2561-4378 surname: Klang fullname: Klang, Victoria email: victoria.klang@univie.ac.at organization: University of Vienna – sequence: 5 givenname: Claudia surname: Valenta fullname: Valenta, Claudia organization: University of Vienna |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31062432$$D View this record in MEDLINE/PubMed |
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| Keywords | confocal raman spectroscopy sulphadiazine sodium tape stripping viscosity skin penetration rheological properties |
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The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features... The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as... BackgroundThe rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features... |
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| SubjectTerms | Animals Anti-Bacterial Agents - pharmacokinetics Cellulose Cellulose - pharmacokinetics Cellulose ethers confocal raman spectroscopy Drug delivery Drug delivery systems Ear, External - metabolism Ether - pharmacokinetics Formulations Gelation Gels High-performance liquid chromatography Hydrogels Hydrogels - chemistry Hydrogels - pharmacokinetics Hydrogen-Ion Concentration Liquid chromatography Original Penetration Raman spectroscopy Rheological properties Rheology - methods Skin Skin - metabolism Skin Absorption - physiology skin penetration Sodium Sulfadiazine - pharmacokinetics sulphadiazine sodium Sus scrofa Swine tape stripping Viscosity |
| Title | The role of viscosity on skin penetration from cellulose ether‐based hydrogels |
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