The role of viscosity on skin penetration from cellulose ether‐based hydrogels

Background The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controvers...

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Vydáno v:Skin research and technology Ročník 25; číslo 5; s. 725 - 734
Hlavní autoři: Binder, Lisa, Mazál, Julia, Petz, Romana, Klang, Victoria, Valenta, Claudia
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.09.2019
John Wiley and Sons Inc
Témata:
Animals
Anti-Bacterial Agents - pharmacokinetics
Cellulose
Cellulose - pharmacokinetics
Cellulose ethers
confocal raman spectroscopy
Drug delivery
Drug delivery systems
Ear, External - metabolism
Ether - pharmacokinetics
Formulations
Gelation
Gels
High-performance liquid chromatography
Hydrogels
Hydrogels - chemistry
Hydrogels - pharmacokinetics
Hydrogen-Ion Concentration
Liquid chromatography
Original
Penetration
Raman spectroscopy
Rheological properties
Rheology - methods
Skin
Skin - metabolism
Skin Absorption - physiology
skin penetration
Sodium
Sulfadiazine - pharmacokinetics
sulphadiazine sodium
Sus scrofa
Swine
tape stripping
Viscosity
confocal raman spectroscopy
sulphadiazine sodium
tape stripping
viscosity
skin penetration
rheological properties
ISSN:0909-752X, 1600-0846, 1600-0846
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Shrnutí:Background The rheological properties of dermal drug delivery systems are of importance when designing new formulations. Viscosity not only affects features such as spreadability and skin feel, but may also affect the skin penetration of incorporated actives. Data on the latter aspect are controversial. Our objective was to elucidate the relation between viscosity and drug delivery performance of different model hydrogels assuming that enhanced microviscosity might delay drug release and penetration. Materials and Methods Hydrogels covering a broad viscosity range were prepared by adding either HPMC or HEC as gelling agents in different concentrations. To investigate the ability of the gels to deliver a model drug into the skin, sulphadiazine sodium was incorporated and its in vitro skin penetration was monitored using tape stripping/HPLC analysis and non‐invasive confocal Raman spectroscopy. Results The trends observed with the two different experimental setups were comparable. Drug penetration depths decreased slightly with increasing viscosity, suggesting slower drug release due to the increasingly dense gel networks. However, the total penetrated drug amounts were independent of the exact formulation viscosity. Conclusion Drug penetration was largely unaffected by hydrogel viscosity. Moderately enhanced viscosity is advisable when designing cellulose ether hydrogels to allow for convenient application.
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ISSN:0909-752X
1600-0846
1600-0846
DOI:10.1111/srt.12709