Sarcopenia and adverse health‐related outcomes: An umbrella review of meta‐analyses of observational studies

Objective The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health‐related outcomes. Design An umbrella review of meta‐analyses of observational studies. Setting and Participants Patients with sarcopenia and controls without sarcopenia were included. M...

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Veröffentlicht in:Cancer medicine (Malden, MA) Jg. 9; H. 21; S. 7964 - 7978
Hauptverfasser: Xia, Lin, Zhao, Rui, Wan, Qianyi, Wu, Yutao, Zhou, Yong, Wang, Yong, Cui, Yaping, Shen, Xiaoding, Wu, Xiaoting
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States John Wiley & Sons, Inc 01.11.2020
John Wiley and Sons Inc
Wiley
Schlagworte:
Age Factors
Aged
AMSTAR
Bias
Bladder cancer
Breast cancer
Clinical Cancer Research
Cognitive ability
Colorectal cancer
Colorectal carcinoma
Comorbidity
Dysphagia
Esophageal cancer
Esophagus
Female
Gastric cancer
GRADE
Head & neck cancer
Health Status
health‐related outcomes
Humans
Liver cancer
Lung cancer
Male
Malignancy
Meta-Analysis as Topic
Metabolic disorders
Metabolism
Middle Aged
Mortality
Musculoskeletal system
Observational studies
Observational Studies as Topic
Older people
Original Research
Ovarian cancer
Pancreatic cancer
Prognosis
Risk Assessment
Risk Factors
Sarcopenia
Sarcopenia - diagnosis
Sarcopenia - epidemiology
Sarcopenia - mortality
Sarcopenia - therapy
Systematic review
Systematic Reviews as Topic
umbrella review
Urothelial cancer
AMSTAR
GRADE
umbrella review
health-related outcomes
sarcopenia
ISSN:2045-7634, 2045-7634
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Zusammenfassung:Objective The purpose of this umbrella review was to assess the associations between sarcopenia and adverse health‐related outcomes. Design An umbrella review of meta‐analyses of observational studies. Setting and Participants Patients with sarcopenia and controls without sarcopenia were included. Measures The PubMed, Web of Science and Embase were searched for relevant systematic review and meta‐analysis. AMSTAR and GRADE system were used for methodological quality and evidence quality assessments, respectively. Results Totally 54 outcomes extracted from 30 meta‐analyses were analyzed. Twenty out of 21 prognostic outcomes indicated that sarcopenia was significantly associated with poorer prognosis of gastric cancer, hepatocellular cancer, urothelial cancer, head and neck cancer, hematological malignancy, pancreatic cancer, breast cancer, colorectal cancer, lung cancer, esophageal cancer, and ovarian cancer. Besides, 10 out of 16 postoperative outcomes suggested that sarcopenia significantly increased the risk of multiple postoperative complications and prolonged the length of hospitalization of patients with digestive cancer. In age‐related outcomes, sarcopenia significantly increased the risk of dysphagia, cognitive impairment, fractures, falls, hospitalization, and all‐cause mortality of elderly populations. Moreover, sarcopenia was also associated with higher level of albuminuria, risk of depression, and several metabolic diseases. Conclusions and Implications Sarcopenia significantly affected a wide range of adverse health‐related outcomes, particularly in patients of tumor and elderly populations. Because evidences of most outcomes were rated as “low” and “very low,” more prospective cohort studies are required in the future. Sarcopenia significantly affected a wide range of adverse health‐related outcomes, particularly in patients of tumor and elderly populations. Besides, associations between sarcopenia and risk of metabolic diseases, depression and albuminuria were also noticeable.
Bibliographie:Funding information
This work was supported by Sichuan Province Science and Technology Support Project (2018SZ0189).
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ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.3428