Natural compounds as potential adjuvants to cancer therapy: Preclinical evidence

Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and a...

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Vydáno v:British journal of pharmacology Ročník 177; číslo 6; s. 1409 - 1423
Hlavní autoři: Lin, Shian‐Ren, Chang, Chia‐Hsiang, Hsu, Che‐Fang, Tsai, May‐Jwan, Cheng, Henrich, Leong, Max K., Sung, Ping‐Jyun, Chen, Jian‐Chyi, Weng, Ching‐Feng
Médium: Journal Article
Jazyk:angličtina
Vydáno: England Blackwell Publishing Ltd 01.03.2020
John Wiley and Sons Inc
Témata:
Adjuvants
Cancer
Cancer therapies
Chemotherapy
Curcumin
Dietary Supplements
Functional foods & nutraceuticals
Herbs
Humans
Matairesinol
Neoplasms - drug therapy
Plant extracts
Resveratrol
Review
Side effects
Themed Section: Review
Toxicity
ISSN:0007-1188, 1476-5381, 1476-5381
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Popis
Shrnutí:Traditional chemotherapy is being considered due to hindrances caused by systemic toxicity. Currently, the administration of multiple chemotherapeutic drugs with different biochemical/molecular targets, known as combination chemotherapy, has attained numerous benefits like efficacy enhancement and amelioration of adverse effects that has been broadly applied to various cancer types. Additionally, seeking natural‐based alternatives with less toxicity has become more important. Experimental evidence suggests that herbal extracts such as Solanum nigrum and Claviceps purpurea and isolated herbal compounds (e.g., curcumin, resveratrol, and matairesinol) combined with antitumoral drugs have the potential to attenuate resistance against cancer therapy and to exert chemoprotective actions. Plant products are not free of risks: Herb adverse effects, including herb–drug interactions, should be carefully considered. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc
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Shian‐Ren Lin and Chia‐Hsiang Chang contribute equally in this study.
ISSN:0007-1188
1476-5381
1476-5381
DOI:10.1111/bph.14816