Deep gray matter volume loss drives disability worsening in multiple sclerosis

Objective Gray matter (GM) atrophy occurs in all multiple sclerosis (MS) phenotypes. We investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS. Methods We analyzed 3,604 brain high‐resolution T1‐weighted magnetic resonance im...

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Vydané v:	Annals of neurology Ročník 83; číslo 2; s. 210 - 222
Hlavní autori:	Eshaghi, Arman, Prados, Ferran, Brownlee, Wallace J., Altmann, Daniel R., Tur, Carmen, Cardoso, M. Jorge, De Angelis, Floriana, van de Pavert, Steven H., Cawley, Niamh, De Stefano, Nicola, Stromillo, M. Laura, Battaglini, Marco, Ruggieri, Serena, Gasperini, Claudio, Filippi, Massimo, Rocca, Maria A., Rovira, Alex, Sastre‐Garriga, Jaume, Vrenken, Hugo, Leurs, Cyra E., Killestein, Joep, Pirpamer, Lukas, Enzinger, Christian, Ourselin, Sebastien, Wheeler‐Kingshott, Claudia A.M. Gandini, Chard, Declan, Thompson, Alan J., Alexander, Daniel C., Barkhof, Frederik, Ciccarelli, Olga
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley Subscription Services, Inc 01.02.2018 John Wiley and Sons Inc
Predmet:	Accumulation Adult Atrophy Atrophy - pathology Brain Brain - diagnostic imaging Brain - pathology Brain stem Cerebellum Confidence intervals Correlation analysis Cortex Disability Evaluation Disease Progression Female Gray Matter - diagnostic imaging Gray Matter - pathology Humans Image Interpretation, Computer-Assisted Longitudinal Studies Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Middle Aged Multiple sclerosis Multiple Sclerosis - diagnostic imaging Multiple Sclerosis - pathology Neuroimaging Neuroimaging - methods Patients Regional analysis Regional development Retrospective Studies Standard deviation Substantia alba Substantia grisea Therapeutic applications
ISSN:	0364-5134, 1531-8249, 1531-8249
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