Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

ABSTRACT This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiologi...

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Vydané v:	Movement disorders Ročník 32; číslo 9; s. 1264 - 1310
Hlavní autori:	Obeso, J.A., Stamelou, M., Goetz, C.G., Poewe, W., Lang, A.E., Weintraub, D., Burn, D., Halliday, G.M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D.J., Rothwell, J.C., Hallett, M., DeLong, M.R., Marras, C., Tanner, C.M., Ross, G.W., Langston, J.W., Klein, C., Bonifati, V., Jankovic, J., Lozano, A.M., Deuschl, G., Bergman, H., Tolosa, E., Rodriguez‐Violante, M., Fahn, S., Postuma, R.B., Berg, D., Marek, K., Standaert, D.G., Surmeier, D.J., Olanow, C.W., Kordower, J.H., Calabresi, P., Schapira, A.H.V., Stoessl, A.J.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Wiley Subscription Services, Inc 01.09.2017
Predmet:	200 years anniversary Anniversaries and Special Events History, 19th Century History, 20th Century History, 21st Century Humans Movement disorders Neurodegenerative diseases Paralysis Parkinson Disease - history Parkinson's disease Shaking Palsy Shaking Palsy Parkinson's disease 200 years anniversary
ISSN:	0885-3185, 1531-8257, 1531-8257
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Shrnutí:	ABSTRACT This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple‐author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society
Bibliografia:	This article was published online on 11 September 2017. After online publication, an update was made to the text. This notice is included in the online and print versions to indicate that both have been corrected on 15 September 2017. Nothing to report. Relevant conflicts of interests/financial disclosures ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23
ISSN:	0885-3185 1531-8257 1531-8257
DOI:	10.1002/mds.27115