Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

ABSTRACT This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiologi...

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Published in:Movement disorders Vol. 32; no. 9; pp. 1264 - 1310
Main Authors: Obeso, J.A., Stamelou, M., Goetz, C.G., Poewe, W., Lang, A.E., Weintraub, D., Burn, D., Halliday, G.M., Bezard, E., Przedborski, S., Lehericy, S., Brooks, D.J., Rothwell, J.C., Hallett, M., DeLong, M.R., Marras, C., Tanner, C.M., Ross, G.W., Langston, J.W., Klein, C., Bonifati, V., Jankovic, J., Lozano, A.M., Deuschl, G., Bergman, H., Tolosa, E., Rodriguez‐Violante, M., Fahn, S., Postuma, R.B., Berg, D., Marek, K., Standaert, D.G., Surmeier, D.J., Olanow, C.W., Kordower, J.H., Calabresi, P., Schapira, A.H.V., Stoessl, A.J.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.09.2017
Subjects:
200 years anniversary
Anniversaries and Special Events
History, 19th Century
History, 20th Century
History, 21st Century
Humans
Movement disorders
Neurodegenerative diseases
Paralysis
Parkinson Disease - history
Parkinson's disease
Shaking Palsy
Shaking Palsy
Parkinson's disease
200 years anniversary
ISSN:0885-3185, 1531-8257, 1531-8257
Online Access:Get full text
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Summary:ABSTRACT This article reviews and summarizes 200 years of Parkinson's disease. It comprises a relevant history of Dr. James Parkinson's himself and what he described accurately and what he missed from today's perspective. Parkinson's disease today is understood as a multietiological condition with uncertain etiopathogenesis. Many advances have occurred regarding pathophysiology and symptomatic treatments, but critically important issues are still pending resolution. Among the latter, the need to modify disease progression is undoubtedly a priority. In sum, this multiple‐author article, prepared to commemorate the bicentenary of the shaking palsy, provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease. © 2017 International Parkinson and Movement Disorder Society
Bibliography:This article was published online on 11 September 2017. After online publication, an update was made to the text. This notice is included in the online and print versions to indicate that both have been corrected on 15 September 2017.
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Relevant conflicts of interests/financial disclosures
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ISSN:0885-3185
1531-8257
1531-8257
DOI:10.1002/mds.27115