Target highlights in CASP13: Experimental target structures through the eyes of their authors

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submi...

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Published in:Proteins, structure, function, and bioinformatics Vol. 87; no. 12; pp. 1037 - 1057
Main Authors: Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, AK, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., Schwede, Torsten
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01.12.2019
Wiley Subscription Services, Inc
Wiley
Subjects:
Arabidopsis - chemistry
Arabidopsis - ultrastructure
Bacterial Proteins - chemistry
Bacterial Proteins - ultrastructure
BASIC BIOLOGICAL SCIENCES
Biochemistry, Molecular Biology
CASP
Casp Experiment Overview
CASP, protein structure prediction
Computational Biology
cryo-EM
Crystallography, X-Ray
Humans
Life Sciences
Models, Molecular
Protein Conformation
protein structure prediction
Proteins - chemistry
Proteins - genetics
Proteins - ultrastructure
Structural Biology
X-ray crystallography
CASP, protein structure prediction
X-ray crystallography
cryo-EM
WD40-repeat
CASP
WDR
D-xylose CASP
PPI
Xyl
D-glucose
D-galactose
DNA damage repair
RING finger and WD repeat domain-containing protein 3
community wide experiment on the Critical Assessment of Techniques for Protein Structure Prediction
DDR
Gal
RFWD3
protein-protein interaction
protein structure prediction
Glc
ISSN:0887-3585, 1097-0134, 1097-0134
Online Access:Get full text
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Summary:The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.
Bibliography:Funding information
ETH Zurich, Grant/Award Number: ETH‐08 14‐1; BBSRC MIBTP studentship, Grant/Award Number: 1500753; U. S. Department of Energy, Grant/Award Numbers: DEAC02‐06CH11357, BER DEFC02‐07ER64494, DE‐AC36‐08GO28308; National Institutes of Health, Grant/Award Numbers: GM098248, GM115586, GM094585, GM117373, GM102318; Wellcome Trust and Royal Society, Grant/Award Numbers: RG170118, 104158/Z/14/Z; Wellcome, Grant/Award Number: 106169/ZZ14/Z; Innovative Medicines Initiative (EU/EFPIA), Grant/Award Number: 115766; Genome Canada; Eshelman Institute for Innovation; Canada Foundation for Innovation; Boehringer Ingelheim; Bayer Pharma AG; AbbVie; NIGMS/NIH, Grant/Award Number: GM100482
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
NREL/JA-2700-74703
AC36-08GO28308
USDOE Office of Science (SC), Biological and Environmental Research (BER)
In memory of pioneer Dr. Jonathan Walton, who deceased on October 18, 2018.
Present address Ignacio Mir‐Sanchis, Department of Medical Biochemistry, Umeå University, Umeå Sweden and Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.
Funding information ETH Zurich, Grant/Award Number: ETH‐08 14‐1; BBSRC MIBTP studentship, Grant/Award Number: 1500753; U. S. Department of Energy, Grant/Award Numbers: DEAC02‐06CH11357, BER DEFC02‐07ER64494, DE‐AC36‐08GO28308; National Institutes of Health, Grant/Award Numbers: GM098248, GM115586, GM094585, GM117373, GM102318; Wellcome Trust and Royal Society, Grant/Award Numbers: RG170118, 104158/Z/14/Z; Wellcome, Grant/Award Number: 106169/ZZ14/Z; Innovative Medicines Initiative (EU/EFPIA), Grant/Award Number: 115766; Genome Canada; Eshelman Institute for Innovation; Canada Foundation for Innovation; Boehringer Ingelheim; Bayer Pharma AG; AbbVie; NIGMS/NIH, Grant/Award Number: GM100482
Correction added on 17 Oct 2019, after first online publication: Author name “Alok Mitra” has been updated to “AK Mitra.”
ISSN:0887-3585
1097-0134
1097-0134
DOI:10.1002/prot.25805