Target highlights in CASP13: Experimental target structures through the eyes of their authors

The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submi...

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Vydáno v:	Proteins, structure, function, and bioinformatics Ročník 87; číslo 12; s. 1037 - 1057
Hlavní autoři:	Lepore, Rosalba, Kryshtafovych, Andriy, Alahuhta, Markus, Veraszto, Harshul A., Bomble, Yannick J., Bufton, Joshua C., Bullock, Alex N., Caba, Cody, Cao, Hongnan, Davies, Owen R., Desfosses, Ambroise, Dunne, Matthew, Fidelis, Krzysztof, Goulding, Celia W., Gurusaran, Manickam, Gutsche, Irina, Harding, Christopher J., Hartmann, Marcus D., Hayes, Christopher S., Joachimiak, Andrzej, Leiman, Petr G., Loppnau, Peter, Lovering, Andrew L., Lunin, Vladimir V., Michalska, Karolina, Mir‐Sanchis, Ignacio, Mitra, AK, Moult, John, Phillips Jr, George N., Pinkas, Daniel M., Rice, Phoebe A., Tong, Yufeng, Topf, Maya, Walton, Jonathan D., Schwede, Torsten
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken, USA John Wiley & Sons, Inc 01.12.2019 Wiley Subscription Services, Inc Wiley
Témata:	Arabidopsis - chemistry Arabidopsis - ultrastructure Bacterial Proteins - chemistry Bacterial Proteins - ultrastructure BASIC BIOLOGICAL SCIENCES Biochemistry, Molecular Biology CASP Casp Experiment Overview CASP, protein structure prediction Computational Biology cryo-EM Crystallography, X-Ray Humans Life Sciences Models, Molecular Protein Conformation protein structure prediction Proteins - chemistry Proteins - genetics Proteins - ultrastructure Structural Biology X-ray crystallography CASP, protein structure prediction X-ray crystallography cryo-EM WD40-repeat CASP WDR D-xylose CASP PPI Xyl D-glucose D-galactose DNA damage repair RING finger and WD repeat domain-containing protein 3 community wide experiment on the Critical Assessment of Techniques for Protein Structure Prediction DDR Gal RFWD3 protein-protein interaction protein structure prediction Glc
ISSN:	0887-3585, 1097-0134, 1097-0134
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Shrnutí:	The functional and biological significance of selected CASP13 targets are described by the authors of the structures. The structural biologists discuss the most interesting structural features of the target proteins and assess whether these features were correctly reproduced in the predictions submitted to the CASP13 experiment.
Bibliografie:	Funding information ETH Zurich, Grant/Award Number: ETH‐08 14‐1; BBSRC MIBTP studentship, Grant/Award Number: 1500753; U. S. Department of Energy, Grant/Award Numbers: DEAC02‐06CH11357, BER DEFC02‐07ER64494, DE‐AC36‐08GO28308; National Institutes of Health, Grant/Award Numbers: GM098248, GM115586, GM094585, GM117373, GM102318; Wellcome Trust and Royal Society, Grant/Award Numbers: RG170118, 104158/Z/14/Z; Wellcome, Grant/Award Number: 106169/ZZ14/Z; Innovative Medicines Initiative (EU/EFPIA), Grant/Award Number: 115766; Genome Canada; Eshelman Institute for Innovation; Canada Foundation for Innovation; Boehringer Ingelheim; Bayer Pharma AG; AbbVie; NIGMS/NIH, Grant/Award Number: GM100482 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 NREL/JA-2700-74703 AC36-08GO28308 USDOE Office of Science (SC), Biological and Environmental Research (BER) In memory of pioneer Dr. Jonathan Walton, who deceased on October 18, 2018. Present address Ignacio Mir‐Sanchis, Department of Medical Biochemistry, Umeå University, Umeå Sweden and Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden. Funding information ETH Zurich, Grant/Award Number: ETH‐08 14‐1; BBSRC MIBTP studentship, Grant/Award Number: 1500753; U. S. Department of Energy, Grant/Award Numbers: DEAC02‐06CH11357, BER DEFC02‐07ER64494, DE‐AC36‐08GO28308; National Institutes of Health, Grant/Award Numbers: GM098248, GM115586, GM094585, GM117373, GM102318; Wellcome Trust and Royal Society, Grant/Award Numbers: RG170118, 104158/Z/14/Z; Wellcome, Grant/Award Number: 106169/ZZ14/Z; Innovative Medicines Initiative (EU/EFPIA), Grant/Award Number: 115766; Genome Canada; Eshelman Institute for Innovation; Canada Foundation for Innovation; Boehringer Ingelheim; Bayer Pharma AG; AbbVie; NIGMS/NIH, Grant/Award Number: GM100482 Correction added on 17 Oct 2019, after first online publication: Author name “Alok Mitra” has been updated to “AK Mitra.”
ISSN:	0887-3585 1097-0134 1097-0134
DOI:	10.1002/prot.25805