Clinical and genetic evaluation after sudden cardiac arrest
Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are...
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| Veröffentlicht in: | Journal of cardiovascular electrophysiology Jg. 31; H. 2; S. 570 - 578 |
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| Sprache: | Englisch |
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01.02.2020
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| Abstract | Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing. |
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| AbstractList | Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing.Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing. Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained1. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at-risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after a SCA/SCD, and discuss the role of genetic testing. Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing. |
| Author | Harris, Stephanie L. Lubitz, Steven A. |
| AuthorAffiliation | 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA 3 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA 1 Cardiovascular Genetics Program, Massachusetts General Hospital, Boston, Massachusetts, USA |
| AuthorAffiliation_xml | – name: 2 Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston, Massachusetts, USA – name: 3 Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA – name: 1 Cardiovascular Genetics Program, Massachusetts General Hospital, Boston, Massachusetts, USA |
| Author_xml | – sequence: 1 givenname: Stephanie L. surname: Harris fullname: Harris, Stephanie L. organization: Massachusetts General Hospital – sequence: 2 givenname: Steven A. orcidid: 0000-0002-9599-4866 surname: Lubitz fullname: Lubitz, Steven A. email: slubitz@mgh.harvard.edu organization: Broad Institute of MIT and Harvard |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31909521$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41436-018-0084-7 10.1038/s41436-018-0338-4 10.1038/gim.2013.204 10.1016/j.jacc.2017.02.046 10.1161/CIRCGENETICS.116.001666 10.1161/HCG.0000000000000054 10.1016/j.hrthm.2011.07.017 10.1161/CIRCULATIONAHA.118.035070 10.1007/s10897-014-9776-6 10.1038/gim.2015.30 10.1007/s10897-017-0175-7 10.1161/CIRCULATIONAHA.108.840827 10.1161/CIRCGENETICS.117.001768 10.1016/j.hrthm.2013.05.014 10.1161/CIRCGENETICS.116.001686 10.1161/CIRCGENETICS.115.001370 10.1001/jamainternmed.2015.7808 10.1016/j.hrthm.2017.10.035 10.1016/j.jacc.2018.04.078 10.1093/europace/eus408 10.1016/j.hrthm.2013.08.022 10.1056/NEJMoa1510687 10.1016/j.jacep.2016.09.019 10.1016/j.hrthm.2019.05.007 10.1002/mgg3.940 10.1161/CIRCGENETICS.117.001844 10.1038/s41431-019-0500-8 10.1093/europace/euv285 10.1016/j.hrthm.2014.01.017 10.1056/NEJMsr1406261 10.1016/j.hrthm.2010.05.036 10.1016/j.tcm.2016.08.010 10.1016/j.amjcard.2019.02.061 10.1161/CIRCULATIONAHA.109.853143 10.1016/j.cardfail.2018.03.004 10.3389/fcvm.2016.00013 10.1002/ajmg.c.30093 10.1007/s10897-014-9743-2 10.1093/europace/eur245 10.1161/CIRCULATIONAHA.104.522581 10.1056/NEJMoa1110186 10.1161/CIRCGEN.119.002460 |
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| Keywords | mutation sudden cardiac arrest gene arrhythmia genetic testing sudden cardiac death cardiomyopathy |
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| Notes | Disclosure Dr Steven A. Lubitz is supported by NIH Grant 1R01HL139731 and American Heart Association 18SFRN34250007. He receives sponsored research support from Bristol Myers Squibb/Pfizer, Bayer AG, and Boehringer Ingelheim, and has consulted for Bristol Myers Squibb/Pfizer and Bayer AG. Other author: No disclosure. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
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| Snippet | Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD... |
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| SubjectTerms | arrhythmia Arrhythmias, Cardiac - complications Arrhythmias, Cardiac - genetics Arrhythmias, Cardiac - physiopathology Arrhythmias, Cardiac - therapy Cardiac arrest Cardiomyopathies - complications Cardiomyopathies - genetics Cardiomyopathies - physiopathology Cardiomyopathies - therapy cardiomyopathy Cardiopulmonary resuscitation Cardiovascular disease Coronary artery CPR Death, Sudden, Cardiac - etiology Death, Sudden, Cardiac - prevention & control Defibrillators DNA Mutational Analysis Electrocardiography Female gene Genetic Predisposition to Disease Genetic screening genetic testing Heart diseases Heredity Humans Male Middle Aged Mutation Pedigree Phenotype Predictive Value of Tests Prognosis Risk Assessment Risk Factors sudden cardiac arrest sudden cardiac death Young Adult |
| Title | Clinical and genetic evaluation after sudden cardiac arrest |
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