Clinical and genetic evaluation after sudden cardiac arrest

Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are...

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Published in:Journal of cardiovascular electrophysiology Vol. 31; no. 2; pp. 570 - 578
Main Authors: Harris, Stephanie L., Lubitz, Steven A.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01.02.2020
Subjects:
arrhythmia
Arrhythmias, Cardiac - complications
Arrhythmias, Cardiac - genetics
Arrhythmias, Cardiac - physiopathology
Arrhythmias, Cardiac - therapy
Cardiac arrest
Cardiomyopathies - complications
Cardiomyopathies - genetics
Cardiomyopathies - physiopathology
Cardiomyopathies - therapy
cardiomyopathy
Cardiopulmonary resuscitation
Cardiovascular disease
Coronary artery
CPR
Death, Sudden, Cardiac - etiology
Death, Sudden, Cardiac - prevention & control
Defibrillators
DNA Mutational Analysis
Electrocardiography
Female
gene
Genetic Predisposition to Disease
Genetic screening
genetic testing
Heart diseases
Heredity
Humans
Male
Middle Aged
Mutation
Pedigree
Phenotype
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
sudden cardiac arrest
sudden cardiac death
Young Adult
mutation
sudden cardiac arrest
gene
arrhythmia
genetic testing
sudden cardiac death
cardiomyopathy
ISSN:1045-3873, 1540-8167, 1540-8167
Online Access:Get full text
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Description
Summary:Sudden cardiac arrest (SCA) and sudden cardiac death (SCD) can be attributed to cardiac, respiratory, metabolic, and toxicologic etiologies. Most cases of SCD are caused by coronary artery disease and approximately 40% of cardiac arrests are unexplained. Inherited arrythmias and cardiomyopathies are important contributors to SCA and SCD. Identifying an inherited condition after such an event not only has important ramifications for the individual, but also for relatives who may be at risk for the familial condition. This review will provide an overview of inherited cardiovascular disorders than can predispose to SCA/SCD, review the diagnostic evaluation for an individual and/or family after an SCA/SCD, and discuss the role of genetic testing.
Bibliography:Disclosure
Dr Steven A. Lubitz is supported by NIH Grant 1R01HL139731 and American Heart Association 18SFRN34250007. He receives sponsored research support from Bristol Myers Squibb/Pfizer, Bayer AG, and Boehringer Ingelheim, and has consulted for Bristol Myers Squibb/Pfizer and Bayer AG. Other author: No disclosure.
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ISSN:1045-3873
1540-8167
1540-8167
DOI:10.1111/jce.14333