Volatile organic compounds in breath can serve as a non‐invasive diagnostic biomarker for the detection of advanced adenomas and colorectal cancer

Summary Background Colorectal cancer (CRC) is the third most common cancer diagnosis in the Western world. Aim To evaluate exhaled volatile organic compounds (VOCs) as a non‐invasive biomarker for the detection of CRC and precursor lesions using an electronic nose. Methods In this multicentre study...

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Vydáno v:	Alimentary pharmacology & therapeutics Ročník 51; číslo 3; s. 334 - 346
Hlavní autoři:	Keulen, Kelly E., Jansen, Maud E., Schrauwen, Ruud W. M., Kolkman, Jeroen J., Siersema, Peter D.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	England Wiley Subscription Services, Inc 01.02.2020 John Wiley and Sons Inc
Témata:	Adenoma Adenoma - diagnosis Adenoma - metabolism Adenoma - pathology Aged Biomarkers Biomarkers, Tumor - analysis Biomarkers, Tumor - metabolism Breath Analysis for Diagnosis of Colorectal Adenomas and Cancer Breath tests Breath Tests - instrumentation Breath Tests - methods Case-Control Studies Colitis Colonoscopy Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - diagnosis Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cross-Sectional Studies Diagnosis Disease Progression Early Detection of Cancer - instrumentation Early Detection of Cancer - methods Electronic Nose - standards Electronic noses Exhalation - physiology Female Humans Inflammatory bowel diseases Intestine Lesions Male Malignancy Middle Aged Models, Biological Neoplasm Staging Netherlands Organic compounds Original Precancerous Conditions - diagnosis Precancerous Conditions - metabolism Precancerous Conditions - pathology Sensitivity and Specificity Tumors VOCs Volatile organic compounds Volatile Organic Compounds - analysis Volatile Organic Compounds - metabolism Netherlands
ISSN:	0269-2813, 1365-2036, 1365-2036
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Shrnutí:	Summary Background Colorectal cancer (CRC) is the third most common cancer diagnosis in the Western world. Aim To evaluate exhaled volatile organic compounds (VOCs) as a non‐invasive biomarker for the detection of CRC and precursor lesions using an electronic nose. Methods In this multicentre study adult colonoscopy patients, without inflammatory bowel disease or (previous) malignancy, were invited for breath analysis. Two‐thirds of the breath tests were randomly assigned to develop training models which were used to predict the diagnosis of the remaining patients (external validation). In the end, all data were used to develop final‐disease models to further improve the discriminatory power of the algorithms. Results Five hundred and eleven breath samples were collected. Sixty‐four patients were excluded due to an inadequate breath test (n = 51), incomplete colonoscopy (n = 8) or colitis (n = 5). Classification was based on the most advanced lesion found; CRC (n = 70), advanced adenomas (AAs) (n = 117), non‐advanced adenoma (n = 117), hyperplastic polyp (n = 15), normal colonoscopy (n = 125). Training models for CRC and AAs had an area under the curve (AUC) of 0.76 and 0.71 and blind validation resulted in an AUC of 0.74 and 0.61 respectively. Final models for CRC and AAs yielded an AUC of 0.84 (sensitivity 95% and specificity 64%) and 0.73 (sensitivity and specificity 79% and 59%) respectively. Conclusions This study suggests that exhaled VOCs could potentially serve as a non‐invasive biomarker for the detection of CRC and AAs. Future studies including more patients could further improve the discriminatory potential of VOC analysis for the detection of (pre‐)malignant colorectal lesions. (https://clinicaltrials.gov Identifier NCT03488537)
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 The Handling Editor for this article was Professor Jonathan Rhodes, and it was accepted for publication after full peer‐review.
ISSN:	0269-2813 1365-2036 1365-2036
DOI:	10.1111/apt.15622