Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders

Objective To use digital histology in a large autopsy cohort of Lewy body disorder (LBD) patients with dementia to test the hypotheses that co‐occurring Alzheimer disease (AD) pathology impacts the anatomic distribution of α‐synuclein (SYN) pathology and that co‐occurring neocortical tau pathology i...

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Veröffentlicht in:	Annals of neurology Jg. 85; H. 2; S. 259 - 271
Hauptverfasser:	Coughlin, David, Xie, Sharon X., Liang, Mendy, Williams, Andrew, Peterson, Claire, Weintraub, Daniel, McMillan, Corey T., Wolk, David A., Akhtar, Rizwan S., Hurtig, Howard I., Branch Coslett, H., Hamilton, Roy H., Siderowf, Andrew D., Duda, John E., Rascovsky, Katya, Lee, Edward B., Lee, Virginia M.‐Y., Grossman, Murray, Trojanowski, John Q., Irwin, David J.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Hoboken, USA John Wiley & Sons, Inc 01.02.2019 Wiley Subscription Services, Inc
Schlagworte:	Aged Aged, 80 and over alpha-Synuclein - metabolism Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - psychology Alzheimer's disease Amyloid Amyloid beta-Peptides - metabolism Autopsies Autopsy Brain - metabolism Brain - pathology Cognitive ability Cognitive tasks Correlation analysis Cortex (entorhinal) Dementia Dementia disorders Entorhinal Cortex - metabolism Entorhinal Cortex - pathology Female Heterogeneity Histology Histopathology Humans Lewy bodies Lewy Body Disease - metabolism Lewy Body Disease - pathology Lewy Body Disease - psychology Male Mental Status and Dementia Tests Movement disorders Neocortex - metabolism Neocortex - pathology Neurodegenerative diseases Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson Disease - psychology Parkinson's disease Pathology Patients Plaque, Amyloid - pathology Putamen Putamen - metabolism Putamen - pathology Synuclein Tau protein tau Proteins - metabolism Temporal cortex Temporal lobe
ISSN:	0364-5134, 1531-8249, 1531-8249
Online-Zugang:	Volltext
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