Neurovascular Unit: A critical role in ischemic stroke

Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a r...

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Vydáno v:CNS neuroscience & therapeutics Ročník 27; číslo 1; s. 7 - 16
Hlavní autoři: Wang, Liyun, Xiong, Xiaoxing, Zhang, Luyuan, Shen, Jian
Médium: Journal Article
Jazyk:angličtina
Vydáno: England John Wiley & Sons, Inc 01.01.2021
John Wiley and Sons Inc
Témata:
Blood vessels
Blood-brain barrier
Brain damage
Cerebrovascular diseases
Edema
Growth factors
Immune response
Inflammation
Ischemia
Medical prognosis
MicroRNAs
Neurons
Neurovascular unit
Permeability
Proteins
Review
Smooth muscle
Stroke
Therapy
Therapy
Stroke
Neurovascular unit
Ischemia
MicroRNAs
ISSN:1755-5930, 1755-5949, 1755-5949
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Abstract Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. Neurovascular unit plays a leading role in the pathophysiological process of ischemic stroke. Both cell‐based therapies and drugs targeting the neurovascular unit can fight against ischemic stroke. The entire multiple cells’ interaction framework of the neurovascular unit are worth to further study to explore the therapeutic potential of the neurovascular unit in clinical.
AbstractList Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. Neurovascular unit plays a leading role in the pathophysiological process of ischemic stroke. Both cell‐based therapies and drugs targeting the neurovascular unit can fight against ischemic stroke. The entire multiple cells’ interaction framework of the neurovascular unit are worth to further study to explore the therapeutic potential of the neurovascular unit in clinical.
Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS.
Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in-depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood-brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS.Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in-depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood-brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS.
Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. Neurovascular unit plays a leading role in the pathophysiological process of ischemic stroke. Both cell‐based therapies and drugs targeting the neurovascular unit can fight against ischemic stroke. The entire multiple cells’ interaction framework of the neurovascular unit are worth to further study to explore the therapeutic potential of the neurovascular unit in clinical.
Author Shen, Jian
Wang, Liyun
Zhang, Luyuan
Xiong, Xiaoxing
AuthorAffiliation 1 Department of Neurosurgery Shengzhou People’s Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch) Shengzhou China
3 Department of Neurosurgery First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China
2 Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan China
AuthorAffiliation_xml – name: 3 Department of Neurosurgery First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China
– name: 2 Department of Neurosurgery Renmin Hospital of Wuhan University Wuhan China
– name: 1 Department of Neurosurgery Shengzhou People’s Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch) Shengzhou China
Author_xml – sequence: 1
  givenname: Liyun
  orcidid: 0000-0001-7608-3787
  surname: Wang
  fullname: Wang, Liyun
  organization: Shengzhou People’s Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch)
– sequence: 2
  givenname: Xiaoxing
  surname: Xiong
  fullname: Xiong, Xiaoxing
  email: xiaoxingxiong@whu.edu.cn
  organization: Renmin Hospital of Wuhan University
– sequence: 3
  givenname: Luyuan
  surname: Zhang
  fullname: Zhang, Luyuan
  organization: Zhejiang University
– sequence: 4
  givenname: Jian
  surname: Shen
  fullname: Shen, Jian
  email: 1314006@zju.edu.cn
  organization: Zhejiang University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33389780$$D View this record in MEDLINE/PubMed
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Copyright_xml – notice: 2021 The Authors. Published by John Wiley & Sons Ltd.
– notice: 2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
– notice: 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 1
Keywords Therapy
Stroke
Neurovascular unit
Ischemia
MicroRNAs
Language English
License Attribution
2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd.
This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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content type line 14
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Wang and Xiong are contributed equally to this work.
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PublicationTitle CNS neuroscience & therapeutics
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John Wiley and Sons Inc
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Snippet Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the...
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SubjectTerms Blood vessels
Blood-brain barrier
Brain damage
Cerebrovascular diseases
Edema
Growth factors
Immune response
Inflammation
Ischemia
Medical prognosis
MicroRNAs
Neurons
Neurovascular unit
Permeability
Proteins
Review
Smooth muscle
Stroke
Therapy
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Title Neurovascular Unit: A critical role in ischemic stroke
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