Serosurveillance after a COVID‐19 vaccine campaign in a Swiss police cohort

Introduction To assess the risk for COVID‐19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross‐sectional investigation was performed before a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurve...

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Vydáno v:Immunity, Inflammation and Disease Ročník 10; číslo 7; s. e640 - n/a
Hlavní autoři: Sendi, Parham, Thierstein, Marc, Widmer, Nadja, Babongo Bosombo, Flora, Büchi, Annina Elisabeth, Güntensperger, Dominik, Blum, Manuel Raphael, Baldan, Rossella, Tinguely, Caroline, Gahl, Brigitta, Heg, Dik, Theel, Elitza S., Berbari, Elie, Endimiani, Andrea, Gowland, Peter, Niederhauser, Christoph
Médium: Journal Article
Jazyk:angličtina
Vydáno: Bognor Regis John Wiley & Sons, Inc 01.07.2022
John Wiley and Sons Inc
Wiley
Témata:
Age groups
Antibodies
anti‐NCP‐antibodies
anti‐S‐antibodies
Comorbidity
Coronaviruses
COVID-19 vaccines
COVID‐19 seroprevalence
Employees
Field study
Immunization
Infections
Original
Pandemics
Population
Questionnaires
SARS‐CoV‐2
Serology
Severe acute respiratory syndrome coronavirus 2
Switzerland
ISSN:2050-4527, 2050-4527
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Shrnutí:Introduction To assess the risk for COVID‐19 of police officers, we are studying the seroprevalence in a cohort. The baseline cross‐sectional investigation was performed before a vaccination campaign in January/February 2021, and demonstrated a seroprevalence of 12.9%. Here, we demonstrate serosurveillance results after a vaccination campaign. Methods The cohort consists of 1022 study participants. The 3‐ and 6‐month follow‐up visits were performed in April/May and September 2021. Data on infection and vaccination rates were obtained via measuring antibodies to the nucleocapsid protein and spike protein and online questionnaires. Results The mean age of the population was 41 (SD 8.8) years, 72% were male and 76% had no comorbidity. Seroconversion was identified in 1.05% of the study population at the 3‐month visit and in 0.73% at the 6‐month visit, resulting in an infection rate of 1.8% over a time period of 6 months. In comparison, the infection rate in the general population over the same time period was higher (3.18%, p = .018). At the 6‐month visit, 77.8% of participants reported being vaccinated once and 70.5% twice; 81% had an anti‐S antibody titer of >250 U/ml and 87.1% of ≥2 U/ml. No significant association between infection and job role within the department, working region, or years of experience in the job was found. Anti‐spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150–200 days after the second vaccine dose. Conclusion These data confirm the value of the vaccination campaign in an exposed group other than healthcare professionals. Graphical In this serosurveillance study, we observed a high vaccination and low infection rate during the delta surge in a police cohort. Anti‐Spike antibody titers of vaccinated study participants showed a calculated decreasing trend 150–200 days after the second vaccine dose.
Bibliografie:Figure 1 is adapted from an open resource website and referenced accordingly. The baseline study using the same cohort of study participants and using the same serology methods and questionnaires have been published elsewhere (Sendi P, Baldan R, Thierstein M, et al.). Here, the follow‐up results after 3 and 6 months are presented.
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ISSN:2050-4527
2050-4527
DOI:10.1002/iid3.640