Computational approaches for simulating luminogenesis

Lumens, liquid-filled cavities surrounded by polarized tissue cells, are elementary units involved in the morphogenesis of organs. Theoretical modeling and computations, which can integrate various factors involved in biophysics of morphogenesis of cell assembly and lumens, may play significant role...

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Veröffentlicht in:Seminars in cell & developmental biology Jg. 131; S. 173 - 185
Hauptverfasser: Fuji, Kana, Tanida, Sakurako, Sano, Masaki, Nonomura, Makiko, Riveline, Daniel, Honda, Hisao, Hiraiwa, Tetsuya
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.11.2022
Elsevier
Schlagworte:
Biological Physics
Cell Polarity
Computational approaches
Luminogenesis
Mathematical modeling
Morphogenesis
Physics
Mathematical modeling
Luminogenesis
Computational approaches
Theoretical modeling
Computational simulations
ISSN:1084-9521, 1096-3634, 1096-3634
Online-Zugang:Volltext
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Zusammenfassung:Lumens, liquid-filled cavities surrounded by polarized tissue cells, are elementary units involved in the morphogenesis of organs. Theoretical modeling and computations, which can integrate various factors involved in biophysics of morphogenesis of cell assembly and lumens, may play significant roles to elucidate the mechanisms in formation of such complex tissue with lumens. However, up to present, it has not been documented well what computational approaches or frameworks can be applied for this purpose and how we can choose the appropriate approach for each problem. In this review, we report some typical lumen morphologies and basic mechanisms for the development of lumens, focusing on three keywords - mechanics, hydraulics and geometry - while outlining pros and cons of the current main computational strategies. We also describe brief guidance of readouts, i.e., what we should measure in experiments to make the comparison with the model’s assumptions and predictions.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1084-9521
1096-3634
1096-3634
DOI:10.1016/j.semcdb.2022.05.021