Neuroimmune-Glia Interactions in the Sensory Ganglia Account for the Development of Acute Herpetic Neuralgia

Herpetic neuralgia is the most important symptom of herpes zoster disease, which is caused by Nevertheless, the pathophysiological mechanisms involved in herpetic neuralgia are not totally elucidated. Here, we examined the neuroimmune interactions at the sensory ganglia that account for the genesis...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of neuroscience Vol. 37; no. 27; p. 6408
Main Authors: Silva, Jaqueline R, Lopes, Alexandre H, Talbot, Jhimmy, Cecilio, Nerry T, Rossato, Mateus F, Silva, Rangel L, Souza, Guilherme R, Silva, Cassia R, Lucas, Guilherme, Fonseca, Benedito A, Arruda, Eurico, Alves-Filho, Jose C, Cunha, Fernando Q, Cunha, Thiago M
Format: Journal Article
Language:English
Published: United States 05.07.2017
Subjects:
Animals
Cells, Cultured
Disease Progression
Ganglia, Sensory - immunology
Leukocytes - immunology
Male
Mice
Mice, Inbred C57BL
Mice, Transgenic
Neuralgia, Postherpetic - immunology
Neuroglia - immunology
Neuroimmunomodulation - immunology
Sensory Receptor Cells - immunology
glial cells
pain
herpes
inflammation
ISSN:1529-2401, 1529-2401
Online Access:Get more information
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Herpetic neuralgia is the most important symptom of herpes zoster disease, which is caused by Nevertheless, the pathophysiological mechanisms involved in herpetic neuralgia are not totally elucidated. Here, we examined the neuroimmune interactions at the sensory ganglia that account for the genesis of herpetic neuralgia using a murine model of Herpes Simplex Virus Type-1 (HSV-1) infection. The cutaneous HSV-1 infection of mice results in the development of a zosteriform-like skin lesion followed by a time-dependent increase in pain-like responses (mechanical allodynia). Leukocytes composed mainly of macrophages and neutrophils infiltrate infected DRGs and account for the development of herpetic neuralgia. Infiltrating leukocytes are responsible for driving the production of TNF, which in turn mediates the development of herpetic neuralgia through downregulation of the inwardly rectifying K channel Kir4.1 in satellite glial cells. These results revealed that neuroimmune-glia interactions at the sensory ganglia play a critical role in the genesis of herpetic neuralgia. In conclusion, the present study elucidates novel mechanisms involved in the genesis of acute herpetic pain and open new avenues for its control. Acute herpetic neuralgia is the most important symptom of herpes zoster disease and it is very difficult to treat. Using a model of peripheral infection of mice with HSV-1, we have characterized for the first time the neuroimmune-glia interactions in the sensory ganglia that account for the development of acute herpetic neuralgia. Among these mechanisms, leukocytes composed mainly of macrophages and neutrophils infiltrate infected sensory ganglia and are responsible for driving the production of TNF. TNF, via TNFR1, mediates herpetic neuralgia development through downregulation of the inwardly rectifying K channel Kir4.1 in satellite glial cells. This study elucidates novel mechanisms involved in the genesis of acute herpetic neuralgia and open new avenues for its control.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1529-2401
1529-2401
DOI:10.1523/JNEUROSCI.2233-16.2017