GPER mediates the angiocrine actions induced by IGF1 through the HIF-1α/VEGF pathway in the breast tumor microenvironment

Background The G protein estrogen receptor GPER/GPR30 mediates estrogen action in breast cancer cells as well as in breast cancer-associated fibroblasts (CAFs), which are key components of microenvironment driving tumor progression. GPER is a transcriptional target of hypoxia inducible factor 1 alph...

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Bibliographic Details
Published in:	Breast cancer research : BCR Vol. 19; no. 1; pp. 129 - 14
Main Authors:	De Francesco, Ernestina M., Sims, Andrew H., Maggiolini, Marcello, Sotgia, Federica, Lisanti, Michael P., Clarke, Robert B.
Format:	Journal Article
Language:	English
Published:	London BioMed Central 06.12.2017 BMC
Subjects:	Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology CAFs Cancer Research Cell Line, Tumor Female Fluorescent Antibody Technique Gene Expression Profiling GPER HIF-1α Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism IGF1 Insulin-Like Growth Factor I - genetics Insulin-Like Growth Factor I - metabolism Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Oncology Receptors, Estrogen - metabolism Receptors, G-Protein-Coupled - metabolism Research Article Signal Transduction - drug effects Surgical Oncology Tumor Microenvironment Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor A - metabolism Vascular Endothelial Growth Factor Receptor-2 - metabolism VEGF CAFs Tumor microenvironment VEGF GPCRs GPER Tumor angiogenesis HIF-1α Breast cancer IGF1 Growth factor receptors
ISSN:	1465-542X, 1465-5411, 1465-542X
Online Access:	Get full text
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