Dietary adzuki bean paste dose-dependently reduces visceral fat accumulation in rats fed a normal diet

[Display omitted] •Adzuki bean paste reduced visceral fat accumulation and serum lipid levels.•A lower energy intake was found in rats fed adzuki bean paste.•End products of cecal fermentation was greater in rats fed adzuki bean paste.•Cecal bacterial 16S rRNA gene sequencing showed that adzuki bean...

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Published in:Food research international Vol. 130; p. 108890
Main Authors: Han, Kyu-Ho, Ohashi, Shunsuke, Sasaki, Keiko, Nagata, Ryuji, Pelpolage, Samanthi, Fukuma, Naoki, Reed, Jess D., Shimada, Ken-ichiro, Kadoya, Norimichi, Fukushima, Michihiro
Format: Journal Article
Language:English
Published: Canada Elsevier Ltd 01.04.2020
Subjects:
acids
Adzuki bean paste
Animals
Bacteroidetes
blood lipids
Cecal bacteria
Cecum - drug effects
Cecum - microbiology
diet
dose response
energy intake
Energy Intake - drug effects
Energy intakes
excretion
Fat accumulation
Fecal lipid excretion
Fermentation
Firmicutes
Gastrointestinal Microbiome - drug effects
Indigestible carbohydrate
intestinal microorganisms
Intra-Abdominal Fat - drug effects
Lipids - blood
Male
microbial communities
Models, Animal
multidimensional scaling
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Rats
Rats, Inbred F344
resistant starch
ribosomal RNA
sequence analysis
species diversity
sterols
Vigna - metabolism
Vigna angularis
visceral fat
water content
Propionic acid (PubChem CID: 1032)
Ammonia- nitrogen (PubChem CID: 6857397)
Indigestible carbohydrate
Adzuki bean paste
Fecal lipid excretion
Acetic acid (PubChem CID: 176)
Cecal bacteria
Fat accumulation
Butyric acid (PubChem CID: 264)
Fermentation
Energy intakes
ISSN:0963-9969, 1873-7145, 1873-7145
Online Access:Get full text
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Summary:[Display omitted] •Adzuki bean paste reduced visceral fat accumulation and serum lipid levels.•A lower energy intake was found in rats fed adzuki bean paste.•End products of cecal fermentation was greater in rats fed adzuki bean paste.•Cecal bacterial 16S rRNA gene sequencing showed that adzuki bean paste reduced the Firmicutes to Bacteroidetes ratio. The aim of this study was to evaluate the dose-dependent effect of adzuki bean (Vigna angularis) paste (ABP) on visceral fat accumulation in rats. ABP is a rich source of indigestible carbohydrates (18.5%) with fiber and resistant starch (RS) contents of 14.5% and 4.0%, respectively. Animals were fed one of the following diets, control (CON), 30% ABP or 58.9% ABP for 28 days. The daily dietary energy intake was lowered (p < 0.05) and reduced visceral fat accumulation and lower serum lipid levels were observed in ABP fed groups. ABP consumption dose-dependently increased (p < 0.05) the daily fecal lipid and fecal acidic sterol excretions. On the other hand, cecal content and fecal moisture content in the 58.9% ABP group were greater (p < 0.05) than the CON group, while there was no significant difference between the two ABP fed groups. Both 30% and 58.9% ABP diets had significantly (p < 0.05) higher contents of cecal acetic, propionic and n-butyric acids, and lowered cecal pH, independently of the ABP dose. Microbial community data of rats fed ABP diets exhibited higher alpha-diversities than the rats fed CON diet, based on the Shannon Index and the number of observed species index, where the two ABP groups exhibited a similar alpha diversity. The weighted UniFrac-based principal coordinate analysis plot of cecal microbial community data showed that the ABP had a substantial effect on the cecal microbial composition. Furthermore, cecal bacterial 16S rRNA gene sequencing revealed that the ABP supplemented diets decreased the ratio of Firmicutes to Bacteroidetes. These findings suggested that the cecal fermentation of fiber and RS in ABP, might have decreased the energy intake, altered the gut microbiota composition, increased fecal lipid output, and thereby reduced fat accumulation in rats.
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ISSN:0963-9969
1873-7145
1873-7145
DOI:10.1016/j.foodres.2019.108890