Gene expression profiling of Ctr9-regulated transcriptome in ERα-positive breast cancer

Ctr9, the key scaffold subunit in human RNA polymerase II associated factor complex (PAFc), has diverse functions in cells and has been implicated in human diseases. Recently, our study found that loss of Ctr9 led to apparent morphological change, decrease of proliferation, and reduced colony format...

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Vydáno v:Genomics data Ročník 7; s. 103 - 104
Hlavní autoři: Zeng, Hao, Xu, Wei
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Elsevier Inc 01.03.2016
Elsevier
Témata:
Breast cancer
breast neoplasms
Ctr9
Data in Brief
DNA-directed RNA polymerase
gene expression
gene expression regulation
human diseases
humans
microarray technology
Microarrays
neoplasm cells
tamoxifen
Transcriptional profiling
transcriptome
women
Ctr9
Breast cancer
Transcriptional profiling
Microarrays
ISSN:2213-5960, 2213-5960
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Shrnutí:Ctr9, the key scaffold subunit in human RNA polymerase II associated factor complex (PAFc), has diverse functions in cells and has been implicated in human diseases. Recently, our study found that loss of Ctr9 led to apparent morphological change, decrease of proliferation, and reduced colony formation in ERα+ breast cancer cells. Moreover, Ctr9 and ERα show positive correlation at protein levels and the high levels of Ctr9 are associated with poor survival among all women with ERα+ breast cancers, and specifically among those treated with tamoxifen. To gain a molecular understanding of the role of Ctr9 in promoting ERα+ breast cancer, we performed a microarray gene expression profiling of Ctr9-regulated transcriptome. Here we provide the experimental details and analysis of the microarray data, which have been deposited into Gene Expression Omnibus (GEO): GSE73388.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:2213-5960
2213-5960
DOI:10.1016/j.gdata.2015.12.006