Consensus Paper: Pathological Role of the Cerebellum in Autism

There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism. In the current consensus paper, we will observe the diversity of opinions regarding the involvement of this important site in the pathology of autism...

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Vydáno v:	Cerebellum (London, England) Ročník 11; číslo 3; s. 777 - 807
Hlavní autoři:	Fatemi, S. Hossein, Aldinger, Kimberly A., Ashwood, Paul, Bauman, Margaret L., Blaha, Charles D., Blatt, Gene J., Chauhan, Abha, Chauhan, Ved, Dager, Stephen R., Dickson, Price E., Estes, Annette M., Goldowitz, Dan, Heck, Detlef H., Kemper, Thomas L., King, Bryan H., Martin, Loren A., Millen, Kathleen J., Mittleman, Guy, Mosconi, Matthew W., Persico, Antonio M., Sweeney, John A., Webb, Sara J., Welsh, John P.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	New York Springer-Verlag 01.09.2012
Témata:	Animals Autistic Disorder - genetics Autistic Disorder - immunology Autistic Disorder - metabolism Autistic Disorder - pathology Autistic Disorder - therapy Biomedical and Life Sciences Biomedicine Cell Adhesion Molecules, Neuronal - metabolism Cerebellar Diseases - genetics Cerebellar Diseases - immunology Cerebellum - immunology Cerebellum - metabolism Cerebellum - pathology Cerebellum - physiopathology Cognition Disorders - etiology Cognition Disorders - physiopathology Disease Models, Animal Extracellular Matrix Proteins - metabolism gamma-Aminobutyric Acid - metabolism Gene-Environment Interaction Glutamic Acid - metabolism Humans Magnetic Resonance Imaging Mitochondria - metabolism Movement Disorders - etiology Movement Disorders - physiopathology Nerve Tissue Proteins - metabolism Neurobiology Neurology Neurosciences Neurotransmitter Agents - metabolism Oxidative Stress Reelin Protein Review Serine Endopeptidases - metabolism Cerebellum Autism
ISSN:	1473-4222, 1473-4230, 1473-4230
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Popis
Shrnutí:	There has been significant advancement in various aspects of scientific knowledge concerning the role of cerebellum in the etiopathogenesis of autism. In the current consensus paper, we will observe the diversity of opinions regarding the involvement of this important site in the pathology of autism. Recent emergent findings in literature related to cerebellar involvement in autism are discussed, including: cerebellar pathology, cerebellar imaging and symptom expression in autism, cerebellar genetics, cerebellar immune function, oxidative stress and mitochondrial dysfunction, GABAergic and glutamatergic systems, cholinergic, dopaminergic, serotonergic, and oxytocin-related changes in autism, motor control and cognitive deficits, cerebellar coordination of movements and cognition, gene–environment interactions, therapeutics in autism, and relevant animal models of autism. Points of consensus include presence of abnormal cerebellar anatomy, abnormal neurotransmitter systems, oxidative stress, cerebellar motor and cognitive deficits, and neuroinflammation in subjects with autism. Undefined areas or areas requiring further investigation include lack of treatment options for core symptoms of autism, vermal hypoplasia, and other vermal abnormalities as a consistent feature of autism, mechanisms underlying cerebellar contributions to cognition, and unknown mechanisms underlying neuroinflammation.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1473-4222 1473-4230 1473-4230
DOI:	10.1007/s12311-012-0355-9