Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice

Microbiota dysbiosis has been linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly understood. The authors tested whether specific changes in the microbiome modulate depressive-like behaviors. Stools from learned helpless, non-learned helpless,...

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Vydané v:	The American journal of psychiatry Ročník 177; číslo 10; s. 974
Hlavní autori:	Medina-Rodriguez, Eva M, Madorma, Derik, O'Connor, Gregory, Mason, Brittany L, Han, Dongmei, Deo, Sapna K, Oppenheimer, Mark, Nemeroff, Charles B, Trivedi, Madhukar H, Daunert, Sylvia, Beurel, Eléonore
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 01.10.2020
Predmet:	Adult Animals Depression - metabolism Depressive Disorder, Major - metabolism Disease Models, Animal Feces - chemistry Female Flow Cytometry Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Helplessness, Learned Humans Interleukin-17 - analysis Male Mice Mice, Inbred C57BL Middle Aged Quorum Sensing Real-Time Polymerase Chain Reaction RNA, Ribosomal, 16S - genetics Serum Amyloid A Protein - analysis Th17 Cells - metabolism Th17 Cells - physiology Autoinducer-2 Depression Th17 Cells Microbiome
ISSN:	1535-7228, 1535-7228
On-line prístup:	Zistit podrobnosti o prístupe
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