Identification of a Signaling Mechanism by Which the Microbiome Regulates Th17 Cell-Mediated Depressive-Like Behaviors in Mice

Microbiota dysbiosis has been linked to major depressive disorder, but the mechanisms whereby the microbiota modulates mood remain poorly understood. The authors tested whether specific changes in the microbiome modulate depressive-like behaviors. Stools from learned helpless, non-learned helpless,...

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Bibliographic Details
Published in:	The American journal of psychiatry Vol. 177; no. 10; p. 974
Main Authors:	Medina-Rodriguez, Eva M, Madorma, Derik, O'Connor, Gregory, Mason, Brittany L, Han, Dongmei, Deo, Sapna K, Oppenheimer, Mark, Nemeroff, Charles B, Trivedi, Madhukar H, Daunert, Sylvia, Beurel, Eléonore
Format:	Journal Article
Language:	English
Published:	United States 01.10.2020
Subjects:	Adult Animals Depression - metabolism Depressive Disorder, Major - metabolism Disease Models, Animal Feces - chemistry Female Flow Cytometry Gastrointestinal Microbiome - genetics Gastrointestinal Microbiome - physiology Helplessness, Learned Humans Interleukin-17 - analysis Male Mice Mice, Inbred C57BL Middle Aged Quorum Sensing Real-Time Polymerase Chain Reaction RNA, Ribosomal, 16S - genetics Serum Amyloid A Protein - analysis Th17 Cells - metabolism Th17 Cells - physiology Autoinducer-2 Depression Th17 Cells Microbiome
ISSN:	1535-7228, 1535-7228
Online Access:	Get more information
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