t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

Tissue-type plasminogen activator (t-PA) is the only thrombolytic treatment available for patients with acute ischaemic stroke. However, t-PA can increase permeability of the blood-brain barrier (BBB). Desmoteplase is a plasminogen activator derived from the common vampire bat, currently under clini...

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Bibliographic Details
Published in:	Brain research Vol. 1565; pp. 63 - 73
Main Authors:	Freeman, Roxann, Niego, Be׳eri, R. Croucher, David, Pedersen, Lars O., Medcalf, Robert L.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 27.05.2014 Elsevier
Subjects:	Biological and medical sciences Blood-brain barrier Blood-Brain Barrier - drug effects Blood-Brain Barrier - metabolism Brain - drug effects Brain - metabolism Cells, Cultured Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Desmoteplase Endothelial Cells - drug effects Endothelial Cells - metabolism Fibrinolytic Agents - pharmacology Fundamental and applied biological sciences. Psychology Glucose - metabolism Humans ICH Medical sciences Neurology Oxygen - metabolism Oxygen-glucose deprivation Permeability Plasmin Plasminogen - pharmacology Plasminogen Activators - pharmacology Stroke Tissue Plasminogen Activator - pharmacology Tissue-type plasminogen activator Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs Stroke BBB ROCK Desmoteplase Oxygen-glucose deprivation CNBr-fgn PFA OGD Plasmin ICH FITC ZO-1 Blood-brain barrier TJ Tissue-type plasminogen activator LRP-1 LDLR t-PA low density lipoprotein receptor LDLR-related protein 1 oxygen-glucose deprivation cyanogen bromide-digested fibrinogen intracerebral haemorrhage paraformaldehyde fluorescein isothiocyanate tissue-type plasminogen activator blood-brain barrier tight-junction Rho-kinase zonula occludens 1 Central nervous system Cardiovascular disease Glucose Blood brain barrier t-Plasminogen activator Encephalon Vascular disease Ischemia Cerebrovascular disease Nervous system diseases Oxygen Deprivation Serine endopeptidases Enzyme Cerebral disorder Peptidases Central nervous system disease Hydrolases Models
ISSN:	0006-8993, 1872-6240, 1872-6240
Online Access:	Get full text
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