Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice

In addition to its surface glycoprotein (GP), Ebola virus directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted into the extracellular space. We recently reported that sGP actively diverts host antibody responses against the epitopes that it shares wit...

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Vydáno v:	The Journal of infectious diseases Ročník 212 Suppl 2; s. S398
Hlavní autoři:	Li, Wenfang, Ye, Ling, Carrion, Jr, Ricardo, Mohan, Gopi S, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L, Compans, Richard W, Yang, Chinglai
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.10.2015
Témata:	Animals Antibodies, Viral - immunology Antibody Formation - immunology Ebola Vaccines - immunology Ebolavirus - immunology Female Glycoproteins - immunology HEK293 Cells Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology Humans Immunization, Secondary - methods Mice Mice, Inbred BALB C Protein Isoforms - immunology Vaccination - methods Vaccines, DNA - immunology Viral Proteins - immunology antigenic subversion vaccine Ebola soluble GP
ISSN:	1537-6613, 1537-6613
On-line přístup:	Zjistit podrobnosti o přístupu
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