Characterization of Immune Responses Induced by Ebola Virus Glycoprotein (GP) and Truncated GP Isoform DNA Vaccines and Protection Against Lethal Ebola Virus Challenge in Mice

In addition to its surface glycoprotein (GP), Ebola virus directs the production of large quantities of a truncated glycoprotein isoform (sGP) that is secreted into the extracellular space. We recently reported that sGP actively diverts host antibody responses against the epitopes that it shares wit...

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Veröffentlicht in:	The Journal of infectious diseases Jg. 212 Suppl 2; S. S398
Hauptverfasser:	Li, Wenfang, Ye, Ling, Carrion, Jr, Ricardo, Mohan, Gopi S, Nunneley, Jerritt, Staples, Hilary, Ticer, Anysha, Patterson, Jean L, Compans, Richard W, Yang, Chinglai
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.10.2015
Schlagworte:	Animals Antibodies, Viral - immunology Antibody Formation - immunology Ebola Vaccines - immunology Ebolavirus - immunology Female Glycoproteins - immunology HEK293 Cells Hemorrhagic Fever, Ebola - immunology Hemorrhagic Fever, Ebola - virology Humans Immunization, Secondary - methods Mice Mice, Inbred BALB C Protein Isoforms - immunology Vaccination - methods Vaccines, DNA - immunology Viral Proteins - immunology antigenic subversion vaccine Ebola soluble GP
ISSN:	1537-6613, 1537-6613
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