Evolving Concepts of Oxidative Stress and Reactive Oxygen Species in Cardiovascular Disease

Cardiovascular disease (CVD) continues to be a substantial health-care burden, despite recent treatment advances. Oxidative stress has long been regarded as a key pathophysiological mediator that ultimately leads to CVD including atherosclerosis, hypertension and heart failure. Over the past decade,...

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Veröffentlicht in:Current atherosclerosis reports Jg. 14; H. 5; S. 476 - 483
Hauptverfasser: Chen, Kai, Keaney, John F.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Current Science Inc 01.10.2012
Schlagworte:
Angiology
Animals
Cardiology
Cardiovascular Diseases - metabolism
Clinical Trials and Their Interpretations (J Plutzky
Humans
Hypertension - metabolism
Medicine
Medicine & Public Health
Mitochondria - metabolism
Oxidative Stress - physiology
Reactive Oxygen Species - metabolism
Section Editor
Signal Transduction - physiology
Hypertension
Oxidative stress
Reactive oxygen species
Antioxidant therapy
Oxidative biomarker
Atherosclerosis
Cardiovascular disease
Oxidative signaling
ISSN:1523-3804, 1534-6242, 1534-6242
Online-Zugang:Volltext
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Zusammenfassung:Cardiovascular disease (CVD) continues to be a substantial health-care burden, despite recent treatment advances. Oxidative stress has long been regarded as a key pathophysiological mediator that ultimately leads to CVD including atherosclerosis, hypertension and heart failure. Over the past decade, emerging evidence has shifted our understanding of reactive oxygen species (ROS) from its harmful role to being signaling molecules. Here, we reviewed recent advances in our understanding of ROS that mediate the complex process of CVDs, with a focus on major ROS signaling and sources such as mitochondria and Nicotinamide Adenine Dinucleotide Phosphate (NADPH) oxidases.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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John F. Keaney, Jr., M.D., Division of Cardiovascular Medicine, Department of Medicine, UMass Medical School, 55 Lake Avenue N., S3-851, Worcester, MA, 01655, Ph:508-334-2266, Fax: 508-856-4571, John.Keaney@umassmed.edu
Kai Chen, M.D., Ph.D., Division of Cardiovascular Medicine, Department of Medicine, UMass Medical School, 55 Lake Avenue N., S3-851, Worcester, MA, 01655, Ph:508-856-3191, Fax: 508-856-4571, Kai.Chen@umassmed.edu
ISSN:1523-3804
1534-6242
1534-6242
DOI:10.1007/s11883-012-0266-8