QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies

In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and...

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Veröffentlicht in:Annals of internal medicine Jg. 155; H. 8; S. 529
Hauptverfasser: Whiting, Penny F, Rutjes, Anne W S, Westwood, Marie E, Mallett, Susan, Deeks, Jonathan J, Reitsma, Johannes B, Leeflang, Mariska M G, Sterne, Jonathan A C, Bossuyt, Patrick M M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 18.10.2011
Schlagworte:
Bias
Diagnosis
Evidence-Based Medicine
Humans
Patient Selection
Quality Control
Reference Standards
Review Literature as Topic
Surveys and Questionnaires
Time Factors
ISSN:1539-3704, 1539-3704
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Zusammenfassung:In 2003, the QUADAS tool for systematic reviews of diagnostic accuracy studies was developed. Experience, anecdotal reports, and feedback suggested areas for improvement; therefore, QUADAS-2 was developed. This tool comprises 4 domains: patient selection, index test, reference standard, and flow and timing. Each domain is assessed in terms of risk of bias, and the first 3 domains are also assessed in terms of concerns regarding applicability. Signalling questions are included to help judge risk of bias. The QUADAS-2 tool is applied in 4 phases: summarize the review question, tailor the tool and produce review-specific guidance, construct a flow diagram for the primary study, and judge bias and applicability. This tool will allow for more transparent rating of bias and applicability of primary diagnostic accuracy studies.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1539-3704
1539-3704
DOI:10.7326/0003-4819-155-8-201110180-00009