Translational and Clinical Applications of Dental Stem Cell-Derived Exosomes

Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration due to their featured properties of self-renewal and multipotency. However, a growing body of evidence has demonstrated that MSCs exert biological functions mainly through secreting exosomes. Exosomes, which con...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Frontiers in genetics Ročník 12; s. 750990
Hlavní autoři: Mai, Zizhao, Chen, Huan, Ye, Yu, Hu, Ziyu, Sun, Wenjuan, Cui, Li, Zhao, Xinyuan
Médium: Journal Article
Jazyk:angličtina
Vydáno: Frontiers Media S.A 26.10.2021
Témata:
clinical application
dental stem cells
exosomes
Genetics
regenerative medicine
tissue repair
ISSN:1664-8021, 1664-8021
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration due to their featured properties of self-renewal and multipotency. However, a growing body of evidence has demonstrated that MSCs exert biological functions mainly through secreting exosomes. Exosomes, which contain RNA, proteins, lipids, and metabolites, are new players in regulating many fundamental processes and play important roles in regenerative medicine. Exosomes not only mimic the effects of their parent cells but also possess many advantages such as high drug loading capacity, low immunogenicity, excellent biocompatibility, and low side effects. Currently, a total of 6 different dental stem cells (DSCs) including dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor cells (DFPCs), stem cells from apical papilla (SCAPs) and gingival mesenchymal stem cells (GMSCs) have been isolated and identified. DSC-derived exosomes (DSC-Exos) are actively involved in intercellular communication, anti-inflammation, osteogenesis, angiogenesis, immunomodulation, nurturing neurons, and promoting tumor cell apoptosis. In this review, we will critically review the emerging role and clinical application potential of DSC-Exos.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
This article was submitted to Stem Cell Research, a section of the journal Frontiers in Genetics
Edited by: Anne George, University of Illinois at Chicago, United States
These authors have contributed equally to this work
Reviewed by: Amar M. Singh, University of Georgia, United States
Philippe Bourin, Independent researcher, Toulouse, France
ISSN:1664-8021
1664-8021
DOI:10.3389/fgene.2021.750990