Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression

Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis based in 135,458 cases and 344,901 controls and identified 44 independent and significant loci. The geneti...

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Published in:	Nature genetics Vol. 50; no. 5; pp. 668 - 681
Main Authors:	Ripke, Stephan, Trzaskowski, Maciej, Byrne, Enda M., Adams, Mark J., Andlauer, Till M. F., Bacanu, Silviu-Alin, Beekman, Aartjan F. T., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas R. H., Bybjerg-Grauholm, Jonas, Castelao, Enrique, Couvy-Duchesne, Baptiste, Craddock, Nick, Deary, Ian J., Finucane, Hilary K., Forstner, Andreas J., Frank, Josef, Gill, Michael, Goes, Fernando S., Grove, Jakob, Hall, Lynsey S., Hannon, Eilis, Hansen, Thomas F., Hickie, Ian B., Hoffmann, Per, Horn, Carsten, Hougaard, David M., Hyde, Craig L., Jorgenson, Eric, Knowles, James A., Kraft, Julia, Krogh, Jesper, Kutalik, Zoltán, Lane, Jacqueline M., Li, Yihan, Li, Yun, Liu, Xiaoxiao, Lu, Leina, MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, Mehta, Divya, Montgomery, Grant W., Nauck, Matthias, Nivard, Michel G., Pedersen, Carsten Bøcker, Posthuma, Danielle, Purcell, Shaun M., Quiroz, Jorge A., Saeed Mirza, Saira, Schoevers, Robert, Schulte, Eva C., Shi, Jianxin, Shyn, Stanley I., Smit, Johannes H., Smith, Daniel J., Stockmeier, Craig A., Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Tian, Chao, Treutlein, Jens, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Weinsheimer, Shantel Marie, Wellmann, Jürgen, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Baune, Bernhard T., Berger, Klaus, de Geus, E. C. J., Domschke, Katharina, Esko, Tõnu, Hinds, David A., Li, Qingqin S., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Müller-Myhsok, Bertram, O’Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Perlis, Roy H., Potash, James B., Schaefer, Catherine, Schulze, Thomas G., Uher, Rudolf, Völzke, Henry, Winslow, Ashley R., Børglum, Anders D.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2018 Nature Publishing Group
Subjects:	692/308/2056 692/699/476 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Body mass Body size Brain Cancer Research Case-Control Studies Consortia Deoxyribonucleic acid Depressive Disorder, Major - genetics DNA DNA methylation Education Educational attainment Etiology Female Gene expression Gene Function Gene loci Genetic Predisposition to Disease Genome-Wide Association Study - methods Genomes Genomics Human Genetics Humans Liability Male Mental depression Mental disorders Meta-analysis Morbidity Multifactorial Inheritance Phenotype Phenotypes Polymorphism, Single Nucleotide Risk analysis Risk Factors Schizophrenia Schizophrenia - genetics Splicing Suicide
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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