Therapeutic targeting of microRNAs: current status and future challenges

Key Points MicroRNAs (miRNAs) have important roles in many aspects of human diseases, and their targeted inhibition may have substantial therapeutic impact. Inhibition of miRNAs can be achieved through a variety of methods and chemically modified antisense oligonucleotides (anti-miRs) have shown the...

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Bibliographic Details
Published in:	Nature reviews. Drug discovery Vol. 13; no. 8; pp. 622 - 638
Main Authors:	Li, Zhonghan, Rana, Tariq M.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 01.08.2014 Nature Publishing Group
Subjects:	631/154/51/391/2310 631/337/384/331 692/699/255 692/699/67 692/699/75 Animals Antisense RNA Biomedicine Biotechnology Cancer Research Drug Delivery Systems Drug Discovery Genetic regulation Genetic research Humans Medicinal Chemistry MicroRNAs - biosynthesis MicroRNAs - drug effects MicroRNAs - physiology Molecular Medicine Pharmacology/Toxicology Properties review-article RNA Interference - drug effects RNA Interference - physiology
ISSN:	1474-1776, 1474-1784, 1474-1784
Online Access:	Get full text
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