Genetics of Insulin Resistance and the Metabolic Syndrome

Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk factors for the development of cardiovascular disease. They result from the interplay of environmental and genetic factors but the full extent of the genetic background to these conditions remains incomplete. Lar...

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Veröffentlicht in:Current cardiology reports Jg. 18; H. 8; S. 75
Hauptverfasser: Brown, Audrey E., Walker, Mark
Format: Journal Article
Sprache:Englisch
Veröffentlicht: New York Springer US 01.08.2016
Schlagworte:
Cardiology
Cardiovascular Genomics (TL Assimes
Cardiovascular Genomics (TL Assimes, Section Editor)
Diabetes Mellitus, Type 2 - complications
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Insulin Resistance - genetics
Lipid Metabolism - genetics
Medicine
Medicine & Public Health
Metabolic Syndrome - genetics
Polymorphism, Single Nucleotide
Section Editor
Topical Collection on Cardiovascular Genomics
Insulin resistance
Common genetic variation
Metabolic syndrome
Genetic risk score
Rare variants
ISSN:1523-3782, 1534-3170, 1534-3170
Online-Zugang:Volltext
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Zusammenfassung:Insulin resistance and the metabolic syndrome are complex metabolic traits and key risk factors for the development of cardiovascular disease. They result from the interplay of environmental and genetic factors but the full extent of the genetic background to these conditions remains incomplete. Large-scale genome-wide association studies have helped advance the identification of common genetic variation associated with insulin resistance and the metabolic syndrome, and more recently, exome sequencing has allowed the identification of rare variants associated with the pathogenesis of these conditions. Many variants associated with insulin resistance are directly involved in glucose metabolism; however, functional studies are required to assess the contribution of other variants to the development of insulin resistance. Many genetic variants involved in the pathogenesis of the metabolic syndrome are associated with lipid metabolism.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:1523-3782
1534-3170
1534-3170
DOI:10.1007/s11886-016-0755-4