Non-structural proteins of bovine viral diarrhea virus

Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs) (i.e., Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, an...

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Vydané v:Virus genes Ročník 58; číslo 6; s. 491 - 500
Hlavní autori: Chi, Shanshan, Chen, Si, Jia, Weijuan, He, Yunjiang, Ren, Linzhu, Wang, Xueli
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: New York Springer US 01.12.2022
Springer Nature B.V
Predmet:
Animals
Biomedical and Life Sciences
Biomedicine
bovine viral diarrhea
Bovine viral diarrhea virus 1
Bovine Virus Diarrhea-Mucosal Disease
Cattle
cattle industry
Cell Line
chronic diseases
Diarrhea
Diarrhea - veterinary
Diarrhea Virus 1, Bovine Viral - genetics
Diarrhea Viruses, Bovine Viral - genetics
Diarrhea Viruses, Bovine Viral - metabolism
Genomes
Medical Microbiology
Plant Sciences
Proteins
Review Paper
RNA
RNA, Viral - genetics
Structural proteins
viral genome
Viral Nonstructural Proteins - metabolism
Virology
virus replication
viruses
Bovine viral diarrhea virus (BVDV)
Functions
Vaccine
Nonstructural proteins (NSPs)
ISSN:0920-8569, 1572-994X, 1572-994X
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Popis
Shrnutí:Bovine viral diarrhea virus (BVDV) belongs to the family Flaviviridae genus pestivirus. The viral genome is a single-stranded, positive-sense RNA that encodes four structural proteins (i.e., C, Erns, E1, and E2) and eight non-structural proteins (NSPs) (i.e., Npro, p7, NS2, NS3, NS4A, NS4B, NS5A, and NS5B). Cattle infected with BVDV exhibit a number of different clinical signs including diarrhea, abortion, and other reproductive disorders which have a serious impact on the cattle industry worldwide. Research on BVDV mainly focuses on its structural protein, however, progress in understanding the functions of the NSPs of BVDV has also been made in recent decades. The knowledge gained on the BVDV non-structural proteins is helpful to more fully understand the viral replication process and the molecular mechanism of viral persistent infection. This review focuses on the functions of BVDV NSPs and provides references for the identification of BVDV, the diagnosis and prevention of Bovine viral diarrhea mucosal disease (BVD-MD), and the development of vaccines.
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Edited by William Dundon.
ISSN:0920-8569
1572-994X
1572-994X
DOI:10.1007/s11262-022-01914-8