Similar dietary regulation of IGF-1- and IGF-binding proteins by animal and plant protein in subjects with type 2 diabetes

Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared...

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Bibliographic Details
Published in:European journal of nutrition Vol. 60; no. 6; pp. 3499 - 3504
Main Authors: Schüler, Rita, Markova, Mariya, Osterhoff, Martin A., Arafat, Ayman, Pivovarova, Olga, Machann, Jürgen, Hierholzer, Johannes, Hornemann, Silke, Rohn, Sascha, Pfeiffer, Andreas F. H.
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.09.2021
Springer Nature B.V
Subjects:
Amino acids
animal proteins
Animals
Bioavailability
Carbohydrates
Chemistry
Chemistry and Materials Science
Diabetes
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2
Diet
energy
Epidemiology
Food sources
Humans
Insulin
insulin resistance
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor Binding Proteins
Insulin-like growth factor I
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factor-binding protein 1
Insulin-like growth factor-binding protein 2
Life span
liver
longevity
mortality
noninsulin-dependent diabetes mellitus
Nutrition
Original Contribution
Plant Proteins
protein intake
Proteins
IGF-binding protein-1
Insulin-like growth factor-1
Plant protein
Animal protein
IGF-binding protein-2
Growth hormone
Protein intake
ISSN:1436-6207, 1436-6215, 1436-6215
Online Access:Get full text
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Summary:Increased animal but not plant protein intake has been associated with increased mortality in epidemiological studies in humans and with reduced lifespan in animal species. Protein intake increases the activity of the IGF-1 system which may provide a link to reduced lifespan. We, therefore, compared the effects of animal versus plant protein intake on circulating levels of IGF-1 and the IGF-binding proteins (IGFBP)-1 and IGFBP-2 over a 6-week period. Thirty seven participants with type 2 diabetes consumed isocaloric diets composed of either 30% energy (EN) animal or plant protein, 30% EN fat and 40% EN carbohydrates for 6 weeks. The participants were clinically phenotyped before and at the end of the study. Both diets induced similar and significant increases of IGF-1 which was unaffected by the different amino acid compositions of plant and animal protein. Despite improvements of insulin sensitivity and major reductions of liver fat, IGFBP2 decreased with both diets while IGFBP-1 was not altered. We conclude that animal and plant protein similarly increase IGF-1 bioavailability while improving metabolic parameters and may be regarded as equivalent in this regard.
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ISSN:1436-6207
1436-6215
1436-6215
DOI:10.1007/s00394-021-02518-y