3D imaging by mass spectrometry: a new frontier

Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on...

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Veröffentlicht in:Analytical chemistry (Washington) Jg. 84; H. 5; S. 2105
Hauptverfasser: Seeley, Erin H, Caprioli, Richard M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 06.03.2012
Schlagworte:
Animals
Brain - anatomy & histology
Humans
Imaging, Three-Dimensional
Magnetic Resonance Imaging
Peptides - chemistry
Proteins - chemistry
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Spectrometry, Mass, Secondary Ion
ISSN:1520-6882, 1520-6882
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Zusammenfassung:Imaging mass spectrometry can generate three-dimensional volumes showing molecular distributions in an entire organ or animal through registration and stacking of serial tissue sections. Here, we review the current state of 3D imaging mass spectrometry as well as provide insights and perspectives on the process of generating 3D mass spectral data along with a discussion of the process necessary to generate a 3D image volume.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ObjectType-Review-3
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ISSN:1520-6882
1520-6882
DOI:10.1021/ac2032707