The gut microbiome of laboratory mice: considerations and best practices for translational research

Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental influences on human physiology, susceptibility to disease, and response to pharmacological intervention, so too does the GM of laboratory mice affect the phenotype of research using mouse models. Multiple expe...

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Bibliographic Details
Published in:Mammalian genome Vol. 32; no. 4; pp. 239 - 250
Main Authors: Ericsson, Aaron C., Franklin, Craig L.
Format: Journal Article
Language:English
Published: New York Springer US 01.08.2021
Springer Nature B.V
Subjects:
Animal Genetics and Genomics
Animal models
Animals
Biomedical and Life Sciences
Cell Biology
Digestive system
Disease Models, Animal
disease susceptibility
Gastrointestinal Microbiome - genetics
genome
Gut microbiota
Human Genetics
human physiology
Humans
Intestinal microflora
intestinal microorganisms
Laboratories
Laboratory animals
Life Sciences
Mice
Microbiomes
Microbiota
Non-pharmacological intervention
phenotype
Phenotypes
Reproducibility
Translational Research, Biomedical
ISSN:0938-8990, 1432-1777, 1432-1777
Online Access:Get full text
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Summary:Just as the gut microbiota (GM) is now recognized as an integral mediator of environmental influences on human physiology, susceptibility to disease, and response to pharmacological intervention, so too does the GM of laboratory mice affect the phenotype of research using mouse models. Multiple experimental factors have been shown to affect the composition of the GM in research mice, as well as the model phenotype, suggesting that the GM represents a major component in experimental reproducibility. Moreover, several recent studies suggest that manipulation of the GM of laboratory mice can substantially improve the predictive power or translatability of data generated in mouse models to the human conditions under investigation. This review provides readers with information related to these various factors and practices, and recommendations regarding methods by which issues with poor reproducibility or translatability can be transformed into discoveries.
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ISSN:0938-8990
1432-1777
1432-1777
DOI:10.1007/s00335-021-09863-7