Neuroserpin, a crucial regulator for axogenesis, synaptic modelling and cell–cell interactions in the pathophysiology of neurological disease

Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, maturation and synaptic refinement. The proteina...

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Vydáno v:Cellular and molecular life sciences : CMLS Ročník 79; číslo 3; s. 172
Hlavní autoři: Godinez, Angela, Rajput, Rashi, Chitranshi, Nitin, Gupta, Veer, Basavarajappa, Devaraj, Sharma, Samridhi, You, Yuyi, Pushpitha, Kanishka, Dhiman, Kunal, Mirzaei, Mehdi, Graham, Stuart, Gupta, Vivek
Médium: Journal Article
Jazyk:angličtina
Vydáno: Cham Springer International Publishing 01.03.2022
Springer Nature B.V
Témata:
Alzheimer's disease
Axons - metabolism
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cell Communication
Cell interactions
Cellular communication
Developmental plasticity
Encephalopathy
Glaucoma
Humans
Inclusion bodies
Life Sciences
Mental disorders
Mutation
Neoplasms - metabolism
Neoplasms - pathology
Nervous System Diseases - metabolism
Nervous System Diseases - pathology
Neurodegenerative diseases
Neurological diseases
Neuronal Plasticity
neurons
Neuropeptides - chemistry
Neuropeptides - metabolism
Neuroserpin
pathophysiology
plasminogen
Plasminogen - metabolism
plasticity
Polymers
Proteinase
Proteinase inhibitors
Proteins
Review
Serpins - chemistry
Serpins - metabolism
Signal Transduction
Signaling
stroke
Synaptic plasticity
Synaptogenesis
t-Plasminogen activator
Therapeutic targets
therapeutics
Thrombolytic drugs
Tissue Plasminogen Activator - metabolism
Glaucoma
Stroke
Serpin
Alzheimer’s disease
Tissue plasminogen activator
Retina
Neuroserpin
Plasminogen
ISSN:1420-682X, 1420-9071, 1420-9071
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Shrnutí:Neuroserpin is an axonally secreted serpin that is involved in regulating plasminogen and its enzyme activators, such as tissue plasminogen activator (tPA). The protein has been increasingly shown to play key roles in neuronal development, plasticity, maturation and synaptic refinement. The proteinase inhibitor may function both independently and through tPA-dependent mechanisms. Herein, we discuss the recent evidence regarding the role of neuroserpin in healthy and diseased conditions and highlight the participation of the serpin in various cellular signalling pathways. Several polymorphisms and mutations have also been identified in the protein that may affect the serpin conformation, leading to polymer formation and its intracellular accumulation. The current understanding of the involvement of neuroserpin in Alzheimer’s disease, cancer, glaucoma, stroke, neuropsychiatric disorders and familial encephalopathy with neuroserpin inclusion bodies (FENIB) is presented. To truly understand the detrimental consequences of neuroserpin dysfunction and the effective therapeutic targeting of this molecule in pathological conditions, a cross-disciplinary understanding of neuroserpin alterations and its cellular signaling networks is essential.
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ISSN:1420-682X
1420-9071
1420-9071
DOI:10.1007/s00018-022-04185-6