Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?

Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic v...

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Bibliographic Details
Published in:Medical oncology (Northwood, London, England) Vol. 34; no. 3; p. 36
Main Authors: Qvick, Alvida, Sorbe, Bengt, Helenius, Gisela, Karlsson, Mats G., Lillsunde Larsson, Gabriella
Format: Journal Article
Language:English
Published: New York Springer US 01.03.2017
Springer Nature B.V
Subjects:
Aged
Cancer
Carcinoma
Carcinoma, Squamous Cell - genetics
Carcinoma, Squamous Cell - virology
Codon
Codon 72
Female
Genes, p53
Genetic Predisposition to Disease
Genital cancers
Hematology
HPV
Human papillomavirus 16 - genetics
Human papillomavirus 16 - isolation & purification
Humans
Internal Medicine
Medicine
Medicine & Public Health
Oncology
Original Paper
P53
Papillomavirus Infections - genetics
Papillomavirus Infections - virology
Pathology
Polymorphism
Polymorphism, Genetic
Real-Time Polymerase Chain Reaction
Tumors
Vagina
Vaginal Neoplasms - genetics
Vaginal Neoplasms - virology
Vulva
Vulvar Neoplasms - genetics
Vulvar Neoplasms - virology
Codon 72
Carcinoma
Vagina
Vulva
P53
Polymorphism
HPV
ISSN:1357-0560, 1559-131X, 1559-131X
Online Access:Get full text
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Summary:Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal ( n  = 66) and vulvar ( n  = 123) carcinomas. In vaginal carcinoma, arginine homozygous patients were significantly associated with a higher primary cure rate ( p  = 0.023) but also associated with a higher recurrence rate ( p  = 0.073), significant at distant locations ( p  = 0.009). No significant differences were found in overall survival rate ( p  = 0.499) or cancer-specific survival rate ( p  = 0.222). A higher frequency of arginine homozygosity was noted in HPV-positive tumors ( p  = 0.190) in comparison with HPV-negative tumors. In vulvar carcinoma, the genotype homozygous for arginine was significantly associated with a larger tumor size at diagnosis in the entire cohort ( p  = 0.015) and a lower cancer-specific survival rate ( p  = 0.024) compared with heterozygous (arginine/proline) in HPV-negative tumors. Our results indicate that the relation between HPV and the p53 codon 72 polymorphism is complex and the significance and mechanisms responsible for this relationship need to be further elucidated.
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ISSN:1357-0560
1559-131X
1559-131X
DOI:10.1007/s12032-017-0893-6