Does p53 codon 72 polymorphism have a prognostic value in carcinoma of the vulva and vagina?

Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic v...

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Veröffentlicht in:	Medical oncology (Northwood, London, England) Jg. 34; H. 3; S. 36
Hauptverfasser:	Qvick, Alvida, Sorbe, Bengt, Helenius, Gisela, Karlsson, Mats G., Lillsunde Larsson, Gabriella
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer US 01.03.2017 Springer Nature B.V
Schlagworte:	Aged Cancer Carcinoma Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - virology Codon Codon 72 Female Genes, p53 Genetic Predisposition to Disease Genital cancers Hematology HPV Human papillomavirus 16 - genetics Human papillomavirus 16 - isolation & purification Humans Internal Medicine Medicine Medicine & Public Health Oncology Original Paper P53 Papillomavirus Infections - genetics Papillomavirus Infections - virology Pathology Polymorphism Polymorphism, Genetic Real-Time Polymerase Chain Reaction Tumors Vagina Vaginal Neoplasms - genetics Vaginal Neoplasms - virology Vulva Vulvar Neoplasms - genetics Vulvar Neoplasms - virology Codon 72 Carcinoma Vagina Vulva P53 Polymorphism HPV
ISSN:	1357-0560, 1559-131X, 1559-131X
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Zusammenfassung:	Human papilloma virus (HPV) is considered to be responsible for a large part of vaginal and vulvar carcinomas, and the p53 codon 72 polymorphism has been implicated in susceptibility to cancer induced by this virus, but with contradicting results. In this study, we have investigated the prognostic value of the codon 72 polymorphism by real-time PCR (qPCR) in two cohorts of vaginal ( n = 66) and vulvar ( n = 123) carcinomas. In vaginal carcinoma, arginine homozygous patients were significantly associated with a higher primary cure rate ( p = 0.023) but also associated with a higher recurrence rate ( p = 0.073), significant at distant locations ( p = 0.009). No significant differences were found in overall survival rate ( p = 0.499) or cancer-specific survival rate ( p = 0.222). A higher frequency of arginine homozygosity was noted in HPV-positive tumors ( p = 0.190) in comparison with HPV-negative tumors. In vulvar carcinoma, the genotype homozygous for arginine was significantly associated with a larger tumor size at diagnosis in the entire cohort ( p = 0.015) and a lower cancer-specific survival rate ( p = 0.024) compared with heterozygous (arginine/proline) in HPV-negative tumors. Our results indicate that the relation between HPV and the p53 codon 72 polymorphism is complex and the significance and mechanisms responsible for this relationship need to be further elucidated.
Bibliographie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	1357-0560 1559-131X 1559-131X
DOI:	10.1007/s12032-017-0893-6