Host genetic control of gut microbiome composition

The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05–0.45), indicating that 5–45% of inter-...

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Published in:Mammalian genome Vol. 32; no. 4; pp. 263 - 281
Main Authors: Bubier, Jason A., Chesler, Elissa J., Weinstock, George M.
Format: Journal Article
Language:English
Published: New York Springer US 01.08.2021
Springer Nature B.V
Subjects:
Abundance
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Digestive system
Disease
disease control
Gastrointestinal Microbiome - genetics
Gene expression
Genetic control
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - microbiology
Genetic diversity
Genetic engineering
Genetic Predisposition to Disease
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genotype & phenotype
Gut microbiota
Heritability
Host-Pathogen Interactions - genetics
Human Genetics
Humans
Intestinal microflora
intestinal microorganisms
Life Sciences
Mice
Mice, Knockout
microbiome
Microbiomes
Microbiota
phenotype
Phenotypes
RNA, Ribosomal, 16S - genetics
Twin studies
ISSN:0938-8990, 1432-1777, 1432-1777
Online Access:Get full text
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Abstract The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05–0.45), indicating that 5–45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
AbstractList The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.The gut microbiome plays a significant role in health and disease, and there is mounting evidence indicating that the microbial composition is regulated in part by host genetics. Heritability estimates for microbial abundance in mice and humans range from (0.05-0.45), indicating that 5-45% of inter-individual variation can be explained by genetics. Through twin studies, genetic association studies, systems genetics, and genome-wide association studies (GWAS), hundreds of specific host genetic loci have been shown to associate with the abundance of discrete gut microbes. Using genetically engineered knock-out mice, at least 30 specific genes have now been validated as having specific effects on the microbiome. The relationships among of host genetics, microbiome composition, and abundance, and disease is now beginning to be unraveled through experiments designed to test causality. The genetic control of disease and its relationship to the microbiome can manifest in multiple ways. First, a genetic variant may directly cause the disease phenotype, resulting in an altered microbiome as a consequence of the disease phenotype. Second, a genetic variant may alter gene expression in the host, which in turn alters the microbiome, producing the disease phenotype. Finally, the genetic variant may alter the microbiome directly, which can result in the disease phenotype. In order to understand the processes that underlie the onset and progression of certain diseases, future research must take into account the relationship among host genetics, microbiome, and disease phenotype, and the resources needed to study these relationships.
Author Chesler, Elissa J.
Weinstock, George M.
Bubier, Jason A.
Author_xml – sequence: 1
  givenname: Jason A.
  orcidid: 0000-0001-5013-1234
  surname: Bubier
  fullname: Bubier, Jason A.
  email: Jason.Bubier@jax.org
  organization: The Jackson Laboratory for Mammalian Genetics
– sequence: 2
  givenname: Elissa J.
  surname: Chesler
  fullname: Chesler, Elissa J.
  organization: The Jackson Laboratory for Mammalian Genetics
– sequence: 3
  givenname: George M.
  surname: Weinstock
  fullname: Weinstock, George M.
  organization: The Jackson Laboratory for Genomic Medicine
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34159422$$D View this record in MEDLINE/PubMed
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2021. The Author(s).
The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Issue 4
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License 2021. The Author(s).
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SubjectTerms Abundance
Animal Genetics and Genomics
Animals
Biomedical and Life Sciences
Cell Biology
Digestive system
Disease
disease control
Gastrointestinal Microbiome - genetics
Gene expression
Genetic control
Genetic Diseases, Inborn - genetics
Genetic Diseases, Inborn - microbiology
Genetic diversity
Genetic engineering
Genetic Predisposition to Disease
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genotype & phenotype
Gut microbiota
Heritability
Host-Pathogen Interactions - genetics
Human Genetics
Humans
Intestinal microflora
intestinal microorganisms
Life Sciences
Mice
Mice, Knockout
microbiome
Microbiomes
Microbiota
phenotype
Phenotypes
RNA, Ribosomal, 16S - genetics
Twin studies
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