Active release of pneumolysin prepores and pores by mammalian cells undergoing a Streptococcus pneumoniae attack

Streptococcus pneumoniae is a potent human pathogen. Its pore-forming exotoxin pneumolysin is instrumental for breaching the host's epithelial barrier and for the incapacitation of the immune system. Using a combination of life imaging and cryo-electron microscopy we show that pneumolysin, rele...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1860; no. 11; pp. 2498 - 2509
Main Authors:	Wolfmeier, Heidi, Radecke, Julika, Schoenauer, Roman, Koeffel, René, Babiychuk, Viktoria S., Drücker, Patrick, Hathaway, Lucy J., Mitchell, Timothy J., Zuber, Benoît, Draeger, Annette, Babiychuk, Eduard B.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.11.2016
Subjects:	Annexin bacteria Bacterial Proteins - pharmacology Bacterial Proteins - toxicity Bacterial toxin bacterial toxins Cell Membrane - drug effects Cell Membrane - microbiology Cell Membrane - ultrastructure Cell Membrane Permeability cryo-electron microscopy epithelium exotoxins HEK293 Cells HeLa Cells homeostasis Humans image analysis mass spectrometry Microvesicle nanotubes pathogens plasma membrane Plasmalemmal repair PLY protein composition proteins Shedding Streptococcus pneumoniae Streptococcus pneumoniae - pathogenicity Streptolysins - pharmacology Streptolysins - toxicity Shedding CDC ALIX HRP HBE FACS FT Hsp90 Vps4 ALG-2 FBS SLO PLY AEC PBS BCA Plasmalemmal repair ESCRT CCD PVDF Microvesicle NAD SDS-PAGE Bacterial toxin HEK 293 Chmp4B PMSS Annexin
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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