Novel mulberry silkworm cocoon-derived carbon dots and their anti-inflammatory properties

Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) deri...

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Published in:Artificial cells, nanomedicine, and biotechnology Vol. 48; no. 1; pp. 68 - 76
Main Authors: Wang, Xiaoke, Zhang, Yue, Kong, Hui, Cheng, Jinjun, Zhang, Meiling, Sun, Ziwei, Wang, Suna, Liu, Jiaxing, Qu, Huihua, Zhao, Yan
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.01.2020
Taylor & Francis Ltd
Taylor & Francis Group
Subjects:
anti-inflammatory
Anti-inflammatory agents
Biological activity
Bombyx mori
Carbon dots
Cocoons
drug discovery
Inflammation
Inflammatory diseases
Interleukin 6
Mulberry silkworm cocoon carbonisata
Pyrolysis
Silkworms
Traditional Chinese medicine
Tumor necrosis factor-α
Tumors
anti-inflammatory
carbon dots
drug discovery
Mulberry silkworm cocoon carbonisata
ISSN:2169-1401, 2169-141X, 2169-141X
Online Access:Get full text
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Summary:Mulberry silkworm cocoon (MSC) carbonisata has been used for the treatment of inflammatory diseases for hundreds of years; however, after years of research efforts, little information is available on its anti-inflammatory components and underlying mechanism. We developed novel carbon dots (CDs) derived from MSC carbonisata (MSC-CDs), for the first time, with an average diameter of 2.26-9.35 nm and a quantum yield (QY) of 6.32%. The MSC-CDs were prepared using a modified pyrolysis method, and no further modification and external surface passivation agent was required. With abundant surface groups, MSC-CDs showed distinct solubility and bioactivity. In this study, we innovatively used three classical experimental models of inflammation to evaluate the anti-inflammatory bioactivity of MSC-CDs. The results indicated that MSC-CDs exhibited marked anti-inflammatory bioactivity which was likely mediated by inhibition of the expression of interleukin-6 and tumour necrosis factor-α. These results suggest that MSC-CDs possess a remarkable anti-inflammatory property, which provides evidence to support further investigation of the considerable potential and effective material basis of this traditional Chinese medicine.
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ISSN:2169-1401
2169-141X
2169-141X
DOI:10.1080/21691401.2019.1699810