Toward a Shared Vision for Cancer Genomic Data

The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded projects. A harmonization process will align sequencing data to the genome and identify mutations and alterations. For the past 2 years, the Nati...

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Veröffentlicht in:The New England journal of medicine Jg. 375; H. 12; S. 1109 - 1112
Hauptverfasser: Grossman, Robert L, Heath, Allison P, Ferretti, Vincent, Varmus, Harold E, Lowy, Douglas R, Kibbe, Warren A, Staudt, Louis M
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Massachusetts Medical Society 22.09.2016
Schlagworte:
Application programming interface
Cancer therapies
Clinical trials
Datasets
Datasets as Topic
DNA, Neoplasm
Gene expression
Genome, Human
Genomes
Genomics
Humans
Information sharing
Medical research
Mutation
National Cancer Institute (U.S.)
Neoplasms - genetics
Precision Medicine
Researchers
Taxonomy
United States
ISSN:0028-4793, 1533-4406
Online-Zugang:Volltext
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Zusammenfassung:The Genomic Data Commons will initially house raw genomic data and diagnostic, histologic, and clinical outcome data from National Cancer Institute–funded projects. A harmonization process will align sequencing data to the genome and identify mutations and alterations. For the past 2 years, the National Cancer Institute (NCI), the University of Chicago, the Ontario Institute for Cancer Research, and Leidos Biomedical Research have been developing an information system called the NCI Genomic Data Commons (GDC) (see figure). The GDC will initially contain raw genomic data as well as diagnostic, histologic, and clinical outcome data from NCI-funded projects such as the Cancer Genome Atlas (TCGA) and the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) program. Unlike previous versions of these data sets, the genomic data will be “harmonized” using uniform analytic pipelines to align the raw sequencing data . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMp1607591