Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta‐analyses

Please cite this paper as: Patra J, Bakker R, Irving H, Jaddoe V, Malini S, Rehm J. Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta‐analyses. BJOG2011;1...

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Veröffentlicht in:BJOG : an international journal of obstetrics and gynaecology Jg. 118; H. 12; S. 1411 - 1421
Hauptverfasser: Patra, J, Bakker, R, Irving, H, Jaddoe, VWV, Malini, S, Rehm, J
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Oxford, UK Blackwell Publishing Ltd 01.11.2011
Blackwell
Wiley Subscription Services, Inc
Schlagworte:
Alcohol
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcohol use
Babies
Biological and medical sciences
Clinical outcomes
Diseases of mother, fetus and pregnancy
Dose-Response Relationship, Drug
Female
Gynecology. Andrology. Obstetrics
Humans
Infant, Low Birth Weight
Infant, Newborn
Infant, Small for Gestational Age
low birthweight
Medical sciences
meta‐analysis
neonatal development
Pregnancy
Pregnancy. Fetus. Placenta
Premature Birth - epidemiology
preterm birth
Regression Analysis
Risk
Risk Factors
small for gestational age
Systematic review
Canada
Consumption
Intrauterine growth retardation
Pregnancy disorders
Gynecology
Low birth weight
Premature delivery
Alcohol
Review
Obstetrics
Pregnancy
Fetal diseases
Newborn diseases
Prematurity
Risk factor
Dose
Bibliographic review
ISSN:1470-0328, 1471-0528, 1471-0528
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Zusammenfassung:Please cite this paper as: Patra J, Bakker R, Irving H, Jaddoe V, Malini S, Rehm J. Dose–response relationship between alcohol consumption before and during pregnancy and the risks of low birthweight, preterm birth and small for gestational age (SGA)—a systematic review and meta‐analyses. BJOG2011;118:1411–1421. Background  Descriptions of the effects of moderate alcohol consumption during pregnancy on adverse pregnancy outcomes have been inconsistent. Objective  To review systematically and perform meta‐analyses on the effect of maternal alcohol exposure on the risk of low birthweight, preterm birth and small for gestational age (SGA). Search strategy  Using Medical Subject Headings, a literature search of MEDLINE, EMBASE, CINAHL, CABS, WHOlist, SIGLE, ETOH, and Web of Science between 1 January 1980 and 1 August 2009 was performed followed by manual searches. Selection criteria  Case–control or cohort studies were assessed for quality (STROBE), 36 available studies were included. Data collection and analysis  Two reviewers independently extracted the information on low birthweight, preterm birth and SGA using a standardised protocol. Meta‐analyses on dose–response relationships were performed using linear as well as first‐order and second‐order fractional polynomial regressions to estimate best fitting curves to the data. Main results  Compared with abstainers, the overall dose–response relationships for low birthweight and SGA showed no effect up to 10 g pure alcohol/day (an average of about 1 drink/day) and preterm birth showed no effect up to 18 g pure alcohol/day (an average of 1.5 drinks/day); thereafter, the relationship showed a monotonically increasing risk for increasing maternal alcohol consumption. Moderate consumption during pre‐pregnancy was associated with reduced risks for all outcomes. Conclusions  Dose–response relationship indicates that heavy alcohol consumption during pregnancy increases the risks of all three outcomes whereas light to moderate alcohol consumption shows no effect. Preventive measures during antenatal consultations should be initiated.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-2
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ObjectType-Review-3
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ISSN:1470-0328
1471-0528
1471-0528
DOI:10.1111/j.1471-0528.2011.03050.x