Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid tumors

Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technol...

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Veröffentlicht in:	Translational research : the journal of laboratory and clinical medicine Jg. 185; S. 58 - 84.e15
Hauptverfasser:	Kowalik, Artur, Kowalewska, Magdalena, Góźdź, Stanisław
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Elsevier Inc 01.07.2017
Schlagworte:	Humans Internal Medicine Lymphatic System Neoplasm Invasiveness Neoplasms - diagnosis Neoplasms - therapy Neoplastic Cells, Circulating AR-V7 EpCAM KRT aCGH ASGR1 ctDNA ICAM1 TWIST mCRPC SERPINE1/PAI1 CDH2 BMDC CDH1 cfDNA RT-PCR PD-L1 PFS PSA VCAM1 NSCLC OS qRT-PCR FN1 HCC M30 EMT DEP ECM AR DTC PSMA CTC FISH NGS FAST EPISPOT MET PCR COPD disseminated tumor cells fluorescent in situ hybridization real-time RT-PCR Fibronectin 1 prostate-specific membrane antigen Keratin androgen receptor overall survival reverse transcription-PCR neoepitope in cytokeratin 18 produced following caspase cleavage during apoptosis circulating tumor DNA programmed death–ligand 1 mesenchymal-to-epithelial transition cell-free DNA dielectrophoresis Twist-related protein 1, also known as TWIST1 non-small-cell lung carcinoma hepatocellular cancer intercellular adhesion molecule epithelial cell adhesion molecule EPithelial ImmunoSPOT method AR splice variant 7 messenger RNA Cadherin 1 bone marrow–derived cells epithelial-mesenchymal transition vascular cell adhesion molecule 1 asialoglycoprotein receptor polymerase chain reaction next-generation sequencing progression-free survival Cadherin 2, type 1, N-cadherin (neuronal) circulating tumor cells metastatic castration–resistant prostate cancer fiber-optic array scanning technology array-comparative genomic hybridization Serpin Peptidase Inhibitor, clade E (Nexin, Plasminogen Activator Inhibitor Type 1), member 1 extracellular matrix chronic obstructive pulmonary disease prostate-specific antigen
ISSN:	1931-5244, 1878-1810, 1878-1810
Online-Zugang:	Volltext
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