Current approaches for avoiding the limitations of circulating tumor cells detection methods—implications for diagnosis and treatment of patients with solid tumors

Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technol...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Translational research : the journal of laboratory and clinical medicine Ročník 185; s. 58 - 84.e15
Hlavní autoři:	Kowalik, Artur, Kowalewska, Magdalena, Góźdź, Stanisław
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.07.2017
Témata:	Humans Internal Medicine Lymphatic System Neoplasm Invasiveness Neoplasms - diagnosis Neoplasms - therapy Neoplastic Cells, Circulating AR-V7 EpCAM KRT aCGH ASGR1 ctDNA ICAM1 TWIST mCRPC SERPINE1/PAI1 CDH2 BMDC CDH1 cfDNA RT-PCR PD-L1 PFS PSA VCAM1 NSCLC OS qRT-PCR FN1 HCC M30 EMT DEP ECM AR DTC PSMA CTC FISH NGS FAST EPISPOT MET PCR COPD disseminated tumor cells fluorescent in situ hybridization real-time RT-PCR Fibronectin 1 prostate-specific membrane antigen Keratin androgen receptor overall survival reverse transcription-PCR neoepitope in cytokeratin 18 produced following caspase cleavage during apoptosis circulating tumor DNA programmed death–ligand 1 mesenchymal-to-epithelial transition cell-free DNA dielectrophoresis Twist-related protein 1, also known as TWIST1 non-small-cell lung carcinoma hepatocellular cancer intercellular adhesion molecule epithelial cell adhesion molecule EPithelial ImmunoSPOT method AR splice variant 7 messenger RNA Cadherin 1 bone marrow–derived cells epithelial-mesenchymal transition vascular cell adhesion molecule 1 asialoglycoprotein receptor polymerase chain reaction next-generation sequencing progression-free survival Cadherin 2, type 1, N-cadherin (neuronal) circulating tumor cells metastatic castration–resistant prostate cancer fiber-optic array scanning technology array-comparative genomic hybridization Serpin Peptidase Inhibitor, clade E (Nexin, Plasminogen Activator Inhibitor Type 1), member 1 extracellular matrix chronic obstructive pulmonary disease prostate-specific antigen
ISSN:	1931-5244, 1878-1810, 1878-1810
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	Eight million people die of cancer each year and 90% of deaths are caused by systemic disease. Circulating tumor cells (CTCs) contribute to the formation of metastases and thus are the subject of extensive research and an abiding interest to biotechnology and pharmaceutical companies. Recent technological advances have resulted in greatly improved CTC detection, enumeration, expansion, and culture methods. However, despite the fact that nearly 150 years have passed since the first detection and description of CTCs in human blood and enormous technological progress that has taken place in this field, especially within the last decade, few CTC detection methods have been approved for routine clinical use. This reflects the substantial methodological problems related to the nature of these cells, their heterogeneity, and diverse metastatic potential. Here, we provide an overview of CTC phenotypes, including the plasticity of CTCs and the relevance of inflammation and cell fusion phenomena for CTC biology. We also review the literature on CTC detection methodology–its recent improvements, clinical significance, and efforts of its clinical application in cancer patients management. At present, CTC detection remains a challenging diagnostic approach as a result of numerous current methodological limitations. This is especially problematic during the early stages of the disease due to the small numbers of CTCs released into the blood of cancer patients. Nonetheless, the rapid development of novel techniques of CTC detection and enumeration in peripheral blood is expected to expedite their implementation in the clinical setting. It is of utmost importance to understand the biology of CTCs and their distinct populations as a prerequisite for achieving this ultimate goal.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1931-5244 1878-1810 1878-1810
DOI:	10.1016/j.trsl.2017.04.002