New advances in exosome-based targeted drug delivery systems

In recent years, various drug nano-delivery platforms have emerged to enhance drug effectiveness in cancer treatment. However, their successful translation to clinics have been hampered by unwanted side effects, as well as associated toxicity. Therefore, there is an imperative need for drug delivery...

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Veröffentlicht in:Critical reviews in oncology/hematology Jg. 172; S. 103628
Hauptverfasser: Ferreira, Débora, Moreira, João Nuno, Rodrigues, Lígia R.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.04.2022
Schlagworte:
Drug delivery systems
Drug Delivery Systems - methods
Exosome
Exosome loading
Exosome surface engineering
Exosomes
Extracellular vesicles
Extracellular Vesicles - pathology
Humans
Neoplasms - drug therapy
Neoplasms - pathology
ILVs
NP
Drug delivery systems
EVs
PS
TRAIL
DSPE
ESCRT
OV
Extracellular vesicles
DOX
Exosome loading
MPS
DDS
MSCs
PEG
Exosome surface engineering
PTX
Exosome
NK
DMPE
MVBs
ISSN:1040-8428, 1879-0461, 1879-0461
Online-Zugang:Volltext
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Zusammenfassung:In recent years, various drug nano-delivery platforms have emerged to enhance drug effectiveness in cancer treatment. However, their successful translation to clinics have been hampered by unwanted side effects, as well as associated toxicity. Therefore, there is an imperative need for drug delivery vehicles capable of surpassing cellular barriers and also efficiently transfer therapeutic payloads to tumor cells. Exosomes, a class of small extracellular vesicles naturally released from all cells, have been exploited as a favorable delivery vehicle due to their natural role in intracellular communication and biocompatibility. In this review, information on exosome biogenesis, contents, forms of isolation and their natural functions is discussed, further complemented with the various successful methodologies for therapeutic payloads encapsulation, including distinct loading approaches. In addition, grafting of molecules to improve pharmacokinetics, tumor homing-ligands, as well as stimuli-responsive elements to enhance cell specificity are also debated. In the end, the current status of clinical-grade exosome-based therapies is outlined. [Display omitted] •Exosomes have been described as efficient delivery vehicles of a myriad of moieties.•Exosomes therapeutic potential can be greatly enhanced by engineering their content.•Multiple exosome surface engineering strategies have been developed.•Aptamers, peptides and antibodies are some of displayed molecules into exosomes.•Great efforts for the development of clinical-grade exosome-based therapies.
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ObjectType-Feature-2
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ISSN:1040-8428
1879-0461
1879-0461
DOI:10.1016/j.critrevonc.2022.103628