A multi-agent cell-based model for wound contraction

A mathematical model for wound contraction is presented. The model is based on a cell-based formalism where fibroblasts, myofibroblasts and the immune reaction are taken into account. The model is used to simulate contraction of a wound using point forces on the cell boundary and it also determines...

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Bibliographic Details
Published in:Journal of biomechanics Vol. 49; no. 8; pp. 1388 - 1401
Main Authors: Boon, W.M., Koppenol, D.C., Vermolen, F.J.
Format: Journal Article
Language:English
Published: United States Elsevier Ltd 24.05.2016
Elsevier Limited
Subjects:
Cell adhesion & migration
Cell Movement
Cell-based modelling
Collagen
Collagen - physiology
Fibroblasts
Fibroblasts - physiology
Finite-element method
Growth factors
Humans
Hybrid approach
Hypothesis testing
Immune system response
Leukocytes - physiology
Mathematical models
Models, Biological
Partial differential equations
Physical Medicine and Rehabilitation
Studies
Wound contraction
Wound healing
Wound Healing - physiology
Finite-element method
Immune system response
Wound contraction
Hybrid approach
Cell-based modelling
ISSN:0021-9290, 1873-2380, 1873-2380
Online Access:Get full text
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Summary:A mathematical model for wound contraction is presented. The model is based on a cell-based formalism where fibroblasts, myofibroblasts and the immune reaction are taken into account. The model is used to simulate contraction of a wound using point forces on the cell boundary and it also determines the orientation of collagen after restoration of the damage. The paper presents the mathematical model in terms of the equations and assumptions, as well as some implications of the modelling. The present model predicts that the amount of final contraction is larger if the migration velocity of the leukocytes is larger and hence it is important that the immune system functions well to prevent contractures. Further, the present model is the first cell-based model that combines the immune system to final contractions.
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ISSN:0021-9290
1873-2380
1873-2380
DOI:10.1016/j.jbiomech.2015.11.058