HEART UK consensus statement on Lipoprotein(a): A call to action

Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) r...

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Vydané v:Atherosclerosis Ročník 291; s. 62 - 70
Hlavní autori: Cegla, Jaimini, Neely, R.Dermot G., France, Michael, Ferns, Gordon, Byrne, Chris D., Halcox, Julian, Datta, Dev, Capps, Nigel, Shoulders, Carol, Qureshi, Nadeem, Rees, Alan, Main, Linda, Cramb, Robert, Viljoen, Adie, Payne, Jules, Soran, Handrean
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Ireland Elsevier B.V 01.12.2019
Predmet:
Cardiovascular risk
Hyperlipidemia
Lipids
Lipoprotein(a)
Lp(a)
Myocardial infarction
Stroke
Myocardial infarction
Lipoprotein(a)
Stroke
Hyperlipidemia
Cardiovascular risk
Lipids
Lp(a)
ISSN:0021-9150, 1879-1484, 1879-1484
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Shrnutí:Lipoprotein(a), Lp(a), is a modified atherogenic low-density lipoprotein particle that contains apolipoprotein(a). Its levels are highly heritable and variable in the population. This consensus statement by HEART UK is based on the evidence that Lp(a) is an independent cardiovascular disease (CVD) risk factor, provides recommendations for its measurement in clinical practice and reviews current and emerging therapeutic strategies to reduce CVD risk. Ten statements summarise the most salient points for practitioners and patients with high Lp(a). HEART UK recommends that Lp(a) is measured in adults as follows: 1) those with a personal or family history of premature atherosclerotic CVD; 2) those with first-degree relatives who have Lp(a) levels >200 nmol/l; 3) patients with familial hypercholesterolemia; 4) patients with calcific aortic valve stenosis and 5) those with borderline (but <15%) 10-year risk of a cardiovascular event. The management of patients with raised Lp(a) levels should include: 1) reducing overall atherosclerotic risk; 2) controlling dyslipidemia with a desirable non-HDL-cholesterol level of <100 mg/dl (2.5 mmol/l) and 3) consideration of lipoprotein apheresis. [Display omitted] •The cardiovascular risk conferred by lipoprotein(a) is determined by the lipoprotein(a) serum concentration.•Serum lipoprotein(a) levels should be measured in five specific population groups.•Recommendations on the management of patients with raised lipoprotein(a) levels (>90 nmol/l) are discussed.
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2019.10.011