Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis

Inconsistent findings have been reported on the association between high-sensitivity C-reactive protein (hs-CRP) and mortality risk. The objective of this meta-analysis was to investigate the association of elevated baseline hs-CRP levels with all-cause, cardiovascular, and cancer mortality risk in...

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Vydáno v:Atherosclerosis Ročník 259; s. 75 - 82
Hlavní autoři: Li, Yunwei, Zhong, Xiaoming, Cheng, Guanchang, Zhao, Cuihua, Zhang, Lei, Hong, Yan, Wan, Qilin, He, Ruili, Wang, Zhizhong
Médium: Journal Article
Jazyk:angličtina
Vydáno: Ireland Elsevier B.V 01.04.2017
Témata:
Adult
Aged
Aged, 80 and over
All-cause mortality
Biomarkers - blood
C-Reactive Protein - analysis
Cardiovascular
Cardiovascular Diseases - blood
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - mortality
Cardiovascular mortality
Cause of Death
High-sensitivity C-reactive protein
Humans
Meta-analysis
Middle Aged
Neoplasms - blood
Neoplasms - diagnosis
Neoplasms - mortality
Odds Ratio
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors
Sex Factors
Up-Regulation
Young Adult
High-sensitivity C-reactive protein
All-cause mortality
Cardiovascular mortality
Meta-analysis
ISSN:0021-9150, 1879-1484, 1879-1484
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Shrnutí:Inconsistent findings have been reported on the association between high-sensitivity C-reactive protein (hs-CRP) and mortality risk. The objective of this meta-analysis was to investigate the association of elevated baseline hs-CRP levels with all-cause, cardiovascular, and cancer mortality risk in the general population. PubMed and Embase were systematically searched for studies published from inception to October 2016. Prospective observational studies were eligible if they reported the effects of elevated baseline hs-CRP levels on cancer-related, cardiovascular or all-cause mortality in the general population. The pooled adjusted risk ratio (RR) with 95% confidence interval (CI) comparing the highest to the lowest category of hs-CRP levels was used as association measures. A total of 83,995 participants from 14 studies were identified. When comparing the highest to the lowest category of hs-CRP levels, the pooled RR was 1.25 (95% CI 1.13–1.38) for cancer-related mortality, 2.03 (95% CI 1.65–2.50) for cardiovascular mortality, and 1.75 (1.55–1.98) for all-cause mortality, respectively. Subgroup analysis showed that the effect of elevated hs-CRP levels on cancer-related mortality was observed in men (RR 1.26; 95% CI 1.11–1.43) but not in women (RR 1.03; 95% CI 0.83–1.27). Elevated hs-CRP levels can independently predict risk of all-cause, cardiovascular mortality in the general population. However, the gender differences in the predictive role of hs-CRP on cancer mortality should to be further investigated. •The predictive value of hs-CRP levels on cancer and all-cause mortality risk is conflicting.•Subjects with the highest hs-CRP levels increased by 75% the risk of all-cause mortality.•Subjects with the highest hs-CRP levels increased by 2.03-fold the risk of cardiovascular mortality.•Hs-CRP can stratify cardiovascular and all-cause mortality risk in the general population.•Gender-specific predictive value of hs-CRP on cancer mortality needs to be further investigated.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0021-9150
1879-1484
1879-1484
DOI:10.1016/j.atherosclerosis.2017.02.003